Oxidative Modification of LDL by Various Physicochemical Techniques: Its Probable Role in Diabetes Coupled with CVDs
المؤلفون المشاركون
Ahmad, Saheem
Alatar, Abdulrahman
Alouffi, Sultan
Faisal, Mohammad
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Pro- and antiatherogenic properties of oxidised low density lipoprotein (Ox-LDL) are responsible for different chronic diseases including diabetes and cardiovascular diseases (CVD).
The constant attack on the body from oxidative stress makes the quantification of various oxidation products necessary.
In this study, the oxidative stress causing the structural and chemical changes occurring in the LDL molecule is comprehensively done.
Moreover, the prevalence of the autoantibodies against the oxidised LDL is also determined.
Methods.
Our study made an attempt to see the effect of Ox-LDL as an enhancer of type 2 diabetes mellitus (T2DM) coupled with CVD.
Primarily, we detected the oxidation of LDL with different concentration of Fenton reaction.
The biochemical parameters were assessed for the changes occurring in the LDL molecule.
In a clinical set up, 20 sera samples were taken from patients who are healthy, 30 from those with diabetes, 20 from those with CVD, and 30 from diabetes with CVD patients.
Results.
In biochemical assays there were markedly increased TBARS, carbonyl, and HMF content in Ox-LDL as compared to native LDL.
The prevalence of autoantibodies against the T2DM was recorded to be 36%, while for CVD it was recorded to be 29%.
However, it was found that 50% of the sera samples showed autoantibodies against oxidized LDL in the sera of T2DM with CVD complications as compared to the native analogue.
Conclusion.
There is significant change in the LDL molecule as revealed by various physicochemical analysis.
The change in the LDL macromolecule as a result of oxidation triggered the development of the autoantibodies against it.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alouffi, Sultan& Faisal, Mohammad& Alatar, Abdulrahman& Ahmad, Saheem. 2018. Oxidative Modification of LDL by Various Physicochemical Techniques: Its Probable Role in Diabetes Coupled with CVDs. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alouffi, Sultan…[et al.]. Oxidative Modification of LDL by Various Physicochemical Techniques: Its Probable Role in Diabetes Coupled with CVDs. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alouffi, Sultan& Faisal, Mohammad& Alatar, Abdulrahman& Ahmad, Saheem. Oxidative Modification of LDL by Various Physicochemical Techniques: Its Probable Role in Diabetes Coupled with CVDs. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر