Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD
المؤلفون المشاركون
Qian, Wei
Zhang, Baihua
Qi, Shouliang
Yue, Yong
Shen, Jing
Li, Chen
Wu, Jianlin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-05
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Dispositions of inhalable particles in the human respiratory tract trigger and exacerbate airway inflammatory diseases.
However, the particle deposition (PD) in airway of subjects with tracheal bronchus (TB) and chronic obstructive pulmonary diseases (COPD) is unknown.
We therefore propose to clarify the disrupted PD associated with TB and COPD using the computational fluid dynamics (CFD) simulation.
Totally nine airway tree models are included.
Six are extracted from CT images of different individuals (two with TB, two with COPD, and two healthy controls (HC)).
The others are the artificially modified models (AMMs) generated by the virtual lesion.
Specifically, they are constructed through artificially adding a tracheal bronchus or a stenosis on one HC model.
The deposition efficiency (DE) and deposition fraction (DF) in these models are obtained by the Euler-Lagrange approach, analyzed, and compared across models, locations, and particle sizes (0.1-10.0 micrometers).
It is found that the PD in models with TB and COPD has been disrupted by the geometrical changes and followed airflow alternations.
DE of the tracheal bronchus is higher for TB models.
For COPD, the stenosis location determines the effects on DE and DF.
Higher DF at the trachea is observed in TB1, TB2, and COPD2 models.
DE increases with the particle size, and DE of the terminal bronchi is higher than that of central regions.
Combined with AMMs, the CFD simulation using realistic airway models demonstrates disruptions of DP.
The methods and findings might help understand the etiology of pulmonary diseases and improve the efficacy of inhaled medicines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Baihua& Qi, Shouliang& Yue, Yong& Shen, Jing& Li, Chen& Qian, Wei…[et al.]. 2018. Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128493
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Baihua…[et al.]. Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1128493
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Baihua& Qi, Shouliang& Yue, Yong& Shen, Jing& Li, Chen& Qian, Wei…[et al.]. Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128493
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128493
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر