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Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study
المؤلفون المشاركون
Cai, Lei
Weng, Jun
He, Guolin
Peng, Qing
Gao, Yi
Li, Yang
Feng, Lei
Fu, Chaoyi
Huo, Xiaolin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality.
However, no available technology can simultaneously support liver and renal function in these patients.
The aim of this study was to evaluate the safety and efficacy of an artificial liver and renal support system in cynomolgus monkeys with surgery-induced ARF.
The ARF model was established by ligature of bilateral renal arteries in eight cynomolgus monkeys, which were randomly divided into a treatment group (n=4) and control group (n=4).
Biochemical indexes were determined before and after surgery.
Blood endotoxin levels, biochemical indexes, and bacterial cultures were assessed at 0, 3, and 6 h during treatment.
System pressures and vital signs were recorded at 1 h intervals.
Pathological examination was performed after death.
ARF was successfully established, based on significant elevation of biochemical indexes and pathological examination.
The treatment group had significantly reduced biochemical indexes relative to the control group.
Measurement of blood endotoxins and aerobic and anaerobic bacteria cultures indicated no bacterial growth.
The system pressures and vital signs were stable during treatment.
The results indicate that our support system for the treatment of cynomolgus monkeys with surgery-induced acute renal failure is safe and effective.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Lei& He, Guolin& Cai, Lei& Fu, Chaoyi& Li, Yang& Weng, Jun…[et al.]. 2018. Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Lei…[et al.]. Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Lei& He, Guolin& Cai, Lei& Fu, Chaoyi& Li, Yang& Weng, Jun…[et al.]. Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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