![](/images/graphics-bg.png)
Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation
المؤلفون المشاركون
Xu, Chang-Sheng
Xie, Liangdi
Zhong, Hong-bin
Wang, Ting-jun
Lian, Gui-li
Wang, Hua-jun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Sick sinus syndrome (SSS) is one of the most common causes of cardiac impairment necessitating pacemaker implantation.
However, studies of SSS pathogenesis are neither comprehensive nor conclusive due to limited success in achieving a stable rat SSS model.
Here, we modified pinpoint press permeation to establish a stable rat SSS model.
Methods.
We randomly assigned 138 male Sprague-Dawley rats into three groups: normal control (n = 8), sham (n = 10), and SSS (n = 120).
Postoperatively, the SSS group was further divided into SSSA (n = 40), SSSB (n = 40), and SSSC (n = 40), based on reduction in heart rates by 20–30%, 31–40%, and 41–50%, respectively.
We also assessed histomorphological characteristics and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 (HCN4) expression in the sinoatrial node (SAN) at 1, 2, 3, and 4 weeks after surgery.
Results.
Mortality was statistically higher in SSSC compared to SSSA and SSSB (7.5% versus 90.0% and 87.5%; P < 0.05).
Heart rate in SSSA was gradually restored to preoperative levels by week 4 after surgery.
In contrast, heart rate in SSSB was stable at 2–3 weeks after surgery.
However, we observed that the tissues and cells in SAN were severely injured and also found a time-dependent increase in collagen content and atrium myocardium in SSSB.
HCN4 expression was significantly reduced at all 4 time points in SSSB, with statistically significant differences among the groups (P < 0.01).
Conclusion.
We successfully developed a rat SSS model that was sustainable for up to 4 weeks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Hong-bin& Wang, Ting-jun& Lian, Gui-li& Xu, Chang-Sheng& Wang, Hua-jun& Xie, Liangdi. 2018. Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128548
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Hong-bin…[et al.]. Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128548
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Hong-bin& Wang, Ting-jun& Lian, Gui-li& Xu, Chang-Sheng& Wang, Hua-jun& Xie, Liangdi. Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128548
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128548
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)