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Effects of Systemic or Local Administration of Zoledronate on Implant Osseointegration: A Preclinical Meta-Analysis
المؤلفون المشاركون
Wu, Xiang-Dong
He, Yao
Chen, Hong
Bao, Wei
Huang, Wei
Li, Zhengyun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
This study aims to investigate the effect of systemically administrated zoledronate on bone-implant fixation in animal models.
Methods.
We searched MEDLINE, Embase, and EBSCO for studies that explore the role of systemic or local zoledronate delivery in implant osseointegration in animal models.
The Review Manager software was used to analyze selected studies by using the weighted mean difference random-effects model.
Analytical data are mainly about bone ingrowth, such as bone-to-implant contact (BIC), bone volume/total volume (BV/TV), and bone area.
Results.
Twenty studies were selected from 182 publications.
The mean quality score was 18/20 for all of the 20 studies (κ = 0.9).
Despite differences in protocols, these studies showed consistent improvement of implant osseointegration with zoledronate administration.
In addition, the osteoporotic animal model, systemic or local administration, sufficient drug dosage, and sample follow-up time were correlated with improved outcomes.
Conclusion.
Systematic administration of zoledronate could improve the osseointegration of orthopedic implant in animal models.
Results of this meta-analysis should be interpreted cautiously because of the inherent differences between preclinical and clinical subjects.
For the local administration, there is a similar trend as well, but the results need to be confirmed and complemented with further analyses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Yao& Bao, Wei& Wu, Xiang-Dong& Huang, Wei& Chen, Hong& Li, Zhengyun. 2019. Effects of Systemic or Local Administration of Zoledronate on Implant Osseointegration: A Preclinical Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Yao…[et al.]. Effects of Systemic or Local Administration of Zoledronate on Implant Osseointegration: A Preclinical Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1128627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Yao& Bao, Wei& Wu, Xiang-Dong& Huang, Wei& Chen, Hong& Li, Zhengyun. Effects of Systemic or Local Administration of Zoledronate on Implant Osseointegration: A Preclinical Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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