23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach
المؤلفون المشاركون
Teja, S. P. Surya
Damodharan, N.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To build and inquire a statistically significant mathematical model for manufacturing methotrexate loaded chitosan nanoparticles (CsNP) of desired particle size.
The study was also performed to evaluate the effect of formulation variables in the explored design space.
Method.
Ionotropic gelation technique was followed for chitosan nanocarriers by changing formulation variables suggested as per Design Expert software.
Altering the levels of Chitosan, tripolyphosphate, methotrexate by 23 factorial design served the purpose.
The CsNP were characterized for nanocarrier formation, particle size, and statistical analysis.
Then mathematical model was statistically analyzed for fabricating desired formulation having particle size less than 200nm.
Results.
FT-IR, XRD reports confirmed the structural change in chitosan which lead to the formation of CsNP.
For particle size, linear model was found to be best fit to explain effect of variables.
Besides, high R2 (0.9958) defends the constancy of constructed model.
Chitosan exhibited higher t-value in Pareto chart and a p-value <0.0001.
Based on maximum desirability, optimization was performed and amount of variables for preparing CsNP of 180nm was predicted.
The experiment was carried out with software suggested combination and particle size was found to be 176±4nm.
Conclusion.
Low p-value endorsed the greater dominance of chitosan on particle size.
Good model adequacy and small percentage error between predicted and experimented value established the reliability of constructed model for robust preparation of CsNP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teja, S. P. Surya& Damodharan, N.. 2018. 23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teja, S. P. Surya& Damodharan, N.. 23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teja, S. P. Surya& Damodharan, N.. 23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر