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Endothelial Function in Children with Acute Lymphoblastic Leukemia (ALL) May Reflect the Clinical Outcome
المؤلفون المشاركون
Mazur, Grzegorz
Szuba, Andrzej
Skomro, Robert
Szahidewicz-Krupska, E.
Doroszko, A.
Jakubowski, Maciej
Derkacz, Arkadiusz
Niedzielska, Ewa
Porwolik, Julita
Turek-Jakubowska, Aleksandra
Sieczkowski, Bartosz
Dobrowolski, Piotr
Radziwon, Aneta
Chybicka, Alicja
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Endothelial dysfunction is a common feature of early complications of hemato-oncologic therapy.
The aim of our study was to assess the profile of endothelial function at diagnosis time, then during initial treatment phase of acute lymphoblastic leukemia (ALL), and to verify the presence of its correlation with early clinical outcome (ECO).
28 ALL children and 18 healthy age-matched control ones were recruited.
Study group was examined at baseline and at 33rd and 78th day of treatment.
At each protocol step the endothelial function was assessed by measurement of sP-selectin (CD62-P), PAI-1(serpinE1), sE-selectin (CD62E), sICAM-1(sCD54), sVCAM-1(sCD106), and VEGF concentrations.
Higher baseline sICAM-1 and sVCAM-1 levels and lower sP-selectin and VEGF were observed in children with ALL.
sICAM-1, sVCAM-1, and sE-selectin levels were decreasing following the treatment with protocol I.
Higher sE-selectin and lower baseline sICAM-1 levels were observed in children treated unsuccessfully.
Lower PAI-1 levels were observed in children who survived.
Higher baseline sE-selectin levels and lower sICAM-1 and VEGF were observed in children treated unsuccessfully.
A decrease in sE-selectin and lower PAI-1 at the 78th day of therapy were associated with better ECO.
High baseline VEGF and sE-selectin levels, significant increase in PAI-1, and low initial sICAM-1 levels are prognostics for poorer prognosis in the ALL children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Doroszko, A.& Niedzielska, Ewa& Jakubowski, Maciej& Porwolik, Julita& Turek-Jakubowska, Aleksandra& Szahidewicz-Krupska, E.…[et al.]. 2018. Endothelial Function in Children with Acute Lymphoblastic Leukemia (ALL) May Reflect the Clinical Outcome. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128775
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Doroszko, A.…[et al.]. Endothelial Function in Children with Acute Lymphoblastic Leukemia (ALL) May Reflect the Clinical Outcome. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128775
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Doroszko, A.& Niedzielska, Ewa& Jakubowski, Maciej& Porwolik, Julita& Turek-Jakubowska, Aleksandra& Szahidewicz-Krupska, E.…[et al.]. Endothelial Function in Children with Acute Lymphoblastic Leukemia (ALL) May Reflect the Clinical Outcome. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128775
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128775
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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