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Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma
المؤلفون المشاركون
Ge, Ming-hua
Qian, Yangyang
Pan, Zongfu
Huang, Ping
Li, Lu
Fang, Qilu
Zhang, Yiwen
Zhu, Junfeng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and rapidly lethal tumors.
However, limited advances have been made to prolong the survival and to reduce the mortality over the last decades.
Therefore, identifying the master regulators underlying ATC progression is desperately needed.
In our present study, three datasets including GSE33630, GSE29265, and GSE65144 were retrieved from Gene Expression Omnibus with a total of 32 ATC samples and 78 normal thyroid tissues.
A total of 1804 consistently changed differentially expressed genes (DEGs) were identified from three datasets.
KEGG pathways enrichment suggested that upregulated DEGs were mainly enriched in ECM-receptor interaction, cell cycle, PI3K-Akt signaling pathway, focal adhesion, and p53 signaling pathway.
Furthermore, key gene modules in PPI network were identified by Cytoscape plugin MCODE and they were mainly associated with DNA replication, cell cycle process, collagen fibril organization, and regulation of leukocyte migration.
Additionally, TOP2A, CDK1, CCNB1, VEGFA, BIRC5, MAPK1, CCNA2, MAD2L1, CDC20, and BUB1 were identified as hub genes of the PPI network.
Interestingly, module analysis showed that 8 out of 10 hub genes participated in Module 1 network and more than 70% genes of Module 2 consisted of collagen family members.
Notably, transcription factors (TFs) regulatory network analysis indicated that E2F7, FOXM1, and NFYB were master regulators of Module 1, while CREB3L1 was the master regulator of Module 2.
Experimental validation showed that CREB3L1, E2F7, and FOXM1 were significantly upregulated in ATC tissue and cell line when compared with normal thyroid group.
In conclusion, the TFs regulatory network provided a more detail molecular mechanism underlying ATC occurrence and progression.
TFs including E2F7, FOXM1, CREB3L1, and NFYB were likely to be master regulators of ATC progression, suggesting their potential role as molecular therapeutic targets in ATC treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Zongfu& Li, Lu& Fang, Qilu& Qian, Yangyang& Zhang, Yiwen& Zhu, Junfeng…[et al.]. 2019. Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Zongfu…[et al.]. Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1128784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Zongfu& Li, Lu& Fang, Qilu& Qian, Yangyang& Zhang, Yiwen& Zhu, Junfeng…[et al.]. Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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