P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis
المؤلفون المشاركون
Zhang, Jun
Guo, Shuai
Wu, Yue
Zheng, Zhi-chao
Wang, Yue
Zhao, Yan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Gastric cancer (GC) is a common tumor-associated lethal disease, and invasiveness and metastasis are primary challenges in its clinical treatment.
Hypoxia microenvironment cannot be ignored in the process of metastasis.
Hypoxia inducible factor-1α (HIF-1α) is the core component of the hypoxia signaling pathway.
The aim of this study was to identify potential hub genes and signaling pathways associated with HIF-1α.
We explored the invasiveness- and metastasis-associated phenotype of GC via bioinformatics analysis and molecular studies.
Differentially expressed genes (DEGs) were identified in GC cells and HIF-1α-knockdown GC cells.
Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, and a protein-protein interaction (PPI) network was constructed.
Hub genes were identified via centrality analysis and Molecular Complex Detection (MCODE) module analysis.
The findings suggested that prolyl 4-hydroxylase beta polypeptide (P4HB) has strong associations with HIF-1α.
Further, we observed that HIF-1α and P4HB were upregulated in SGC-7901 and BGC-823 cells.
In addition, inhibition of HIF-1α expression reduced invasion and metastasis in GC cells; this effect was partially reversed by P4HB overexpression.
Our results confirm that P4HB plays a significant role in the regulatory network of HIF-1α.
Therefore, HIF-1α and P4HB may be considered potential biomarkers of GC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jun& Guo, Shuai& Wu, Yue& Zheng, Zhi-chao& Wang, Yue& Zhao, Yan. 2019. P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jun…[et al.]. P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1128803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jun& Guo, Shuai& Wu, Yue& Zheng, Zhi-chao& Wang, Yue& Zhao, Yan. P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر