Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow
المؤلفون المشاركون
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
We investigate numerically the microscale blood flow in which red blood cells (RBCs) are partially infected by Plasmodium falciparum, the malaria parasite.
The infected RBCs are modeled as more rigid cells with less deformability than healthy ones.
Our study illustrates that, in a 10 μm microvessel in low-hematocrit conditions (18% and 27%), the Plasmodium falciparum-infected red blood cells (Pf-IRBCs) and healthy ones first form a train of cells.
Because of the slow moving of the Pf-IRBCs, the local hematocrit (Hct) near the Pf-IRBCs is then increased, to approximately 40% or even higher values.
This increase of the local hematocrit is temporary and is kept for a longer length of time because of the long RBC train formed in 27%-Hct condition.
Similar hematocrit elevation at the downstream region with 45%-Hct in the same 10 μm microvessel is also observed with the cells randomly located.
In 20 μm microvessels with 45%-Hct, the Pf-IRBCs slow down the velocity of the healthy red blood cells (HRBCs) around them and then locally elevate the volume fraction and result in the accumulation of the RBCs at the center of the vessels, thus leaving a thicker cell free layer (CFL) near the vessel wall than normal.
Variation of wall shear stress (WSS) is caused by the fluctuation of local Hct and the distance between the wall and the RBCs.
Moreover, in high-hematocrit condition (45%), malaria-infected cells have a tendency to migrate to the edge of the aggregates which is due to the uninterrupted hydrodynamic interaction between the HRBCs and Pf-IRBC.
Our results suggest that the existence of Pf-IRBCs is a nonnegligible factor for the fluctuation of hematocrit and WSS and also contributes to the increase of CFL of pathological blood flow in microvessels.
The numerical approach presented has the potential to be utilized to RBC disorders and other hematologic diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Tong& Xing, Zhongwen. 2018. Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Tong& Xing, Zhongwen. Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1128875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Tong& Xing, Zhongwen. Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر