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Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience
المؤلفون المشاركون
Pavone, Piero
Ruggieri, Martino
Falsaperla, Raffaele
Mauceri, Laura
Barbagallo, Massimo
Corsello, Giovanni
Pisani, Francesco
Vitaliti, Giovanna
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Phenobarbital (PB) has been traditionally used as the first-line treatment for neonatal seizures.
More recently, levetiracetam (LEV) has been increasingly used as a promising newer antiepileptic medication for treatment of seizures in neonates.
Objectives.
The aim of our study was to compare the effect of PB vs.
LEV on short-term neurodevelopmental outcome in infants treated for neonatal seizures.
Method.
This randomized, one-blind prospective study was conducted on term neonates admitted to the Neonatal Intensive Care Unit of S.
Bambino Hospital, University Hospital “Policlinico-Vittorio Emanuele,” Catania, Italy, from February 2016 to February 2018.
Thirty term neonates with seizures were randomized to receive PB or LEV; the Hammersmith Neonatal Neurological Examination (HNNE) was used at baseline (T0) and again one month after the initial treatment (T1).
Results.
We found a significantly positive HNNE score for the developmental outcomes, specifically tone and posture, in neonates treated with LEV.
There was no significant improvement in the HNNE score at T1 in the neonates treated with PB.
Conclusion.
This study suggests a positive effect of levetiracetam on tone and posture in term newborns treated for neonatal seizures.
If future randomized-controlled studies also show better efficacy of LEV in the treatment of neonatal seizures, LEV might potentially be considered as the first-line anticonvulsant in this age group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Falsaperla, Raffaele& Mauceri, Laura& Pavone, Piero& Barbagallo, Massimo& Vitaliti, Giovanna& Ruggieri, Martino…[et al.]. 2019. Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128973
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Falsaperla, Raffaele…[et al.]. Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience. Behavioural Neurology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1128973
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Falsaperla, Raffaele& Mauceri, Laura& Pavone, Piero& Barbagallo, Massimo& Vitaliti, Giovanna& Ruggieri, Martino…[et al.]. Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128973
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128973
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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