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Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression
المؤلفون المشاركون
Shim, Insop
Kim, Young-Hwa
Kim, Yu Ri
Park, Bo-Kyung
Kang, In-Cheol
Lee, Mi-Young
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Prolonged exposure to stress can affect mood and cognition and lead to mood disorders.
Research on stress-associated mood disorders is important in modern society as people are increasingly exposed to unavoidable stressors.
We used a mouse model with 2 weeks of exposure to electric foot shock and restraint, to determine the effect of Fraxinus rhynchophylla Hance (FX) extract on chronic stress-induced depression.
We measured the effect of FX extract using various physiological, behavioral, and biochemical measures.
FX extract ameliorated chronic stress-induced body and relative liver weight loss and improved depressive-like behaviors in the open field and forced swim tests.
In addition, plasma cortisol and serotonin levels in stress-induced mice following FX treatment were similar to normal mice, and the elevation of proinflammatory cytokines was prevented.
Moreover, FX treatment increased the expression of phosphorylated cyclic adenosine-3′,5′-monophosphate response element-binding protein (pCREB)/brain-derived neurotrophic factor (BDNF).
Further experiments confirmed the efficacy of FX extract by showing similar results using esculin and esculetin, compounds extracted from FX.
Taken together, these results indicate that FX extract has an antidepressant effect on chronic stress-induced depression by associating signaling with neuroinflammation and neurogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Yu Ri& Park, Bo-Kyung& Kim, Young-Hwa& Shim, Insop& Kang, In-Cheol& Lee, Mi-Young. 2018. Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129000
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Yu Ri…[et al.]. Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1129000
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Yu Ri& Park, Bo-Kyung& Kim, Young-Hwa& Shim, Insop& Kang, In-Cheol& Lee, Mi-Young. Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129000
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129000
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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