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Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression
المؤلفون المشاركون
Scévola, Laura
Solis, Patricia
D’Alessio, Luciana
Konopka, Hector
Lima, Mónica Fernandez
Nuñez, Claudio
Seoane, Eduardo
Oddo, Silvia
Kochen, Silvia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions.
The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits.
Methods.
Selected hippocampal samples from patients with TLE who underwent epilepsy surgery were included.
Clinical and complementary assessment: EEG, video-EEG, MRI, psychiatric assessment (structured clinical interview, DSM-IV), and memory assessment (Rey auditory verbal learning test, RAVLT; Rey-Osterrieth complex figure test, RCFT), were determined before surgery.
Hippocampal sections were processed using immunoperoxidase with the anti-calbindin antibody.
The semiquantitative analysis of CB immunoreactivity was determined in dentate gyrus by computerized image analysis (ImageJ).
Results.
Hippocampal sections of patients with TLE and HS (n=24) and postmortem controls (n=5) were included.
A significant reduction of CB+ cells was found in patients with TLE (p<0.05, Student’s t-test).
Among TLE cases (n=24), depression (n=12) and memory deficit (n=17) were determined.
Depression was associated with a higher % of cells with the CB dendritic expression (CB-sprouted cells) (F1,20=11.81, p=0.003, hp2=0.37), a higher CB+ area (μm2) (F1,20=5.33, p=0.032, hp2=0.21), and a higher optical density (F1,20=15.09, p=0.001, hp2=0.43) (two-way ANOVA).
The GAF scale (general assessment of functioning) of DSM-IV inversely correlated with the % of CB-sprouted cells (r=−0.52, p=0.008) and with the CB+ area (r=−0.46, p=0.022).
Conclusions.
In this exploratory study, comorbid depression was associated with a differential pattern of CB cell loss in dentate gyrus combined with a higher CB sprouting.
These changes may indicate granular cell dysmaturation associated to the epileptic hyperexcitability phenomena.
Further investigations should be carried out to confirm these preliminary findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
D’Alessio, Luciana& Konopka, Hector& Solis, Patricia& Scévola, Laura& Lima, Mónica Fernandez& Nuñez, Claudio…[et al.]. 2019. Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1129014
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
D’Alessio, Luciana…[et al.]. Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression. Behavioural Neurology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1129014
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
D’Alessio, Luciana& Konopka, Hector& Solis, Patricia& Scévola, Laura& Lima, Mónica Fernandez& Nuñez, Claudio…[et al.]. Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1129014
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129014
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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