Infections Caused by Extended-Spectrum β-Lactamase Producing Escherichia Coli in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model
المؤلفون المشاركون
Shen, Hui
Zhu, Cheng
Yu, Yuetian
Guo, Ruru
Gao, Yuan
Lu, Liangjing
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the prevalence and risk factors of infections caused by Extended-Spectrum β-Lactamase (ESBL) producing Escherichia coli (E.
coli) in systemic lupus erythematosus (SLE) patients and develop a predictive model.
Methods.
Three hundred and eighty-four consecutive SLE patients with E.
coli infection were enrolled in this retrospective case control study from January 2012 to December 2017.
Prevalence and antimicrobial susceptibility pattern of ESBL producing E.
coli were analyzed.
Multivariate analysis was performed to determine the risk factors.
Sensitivity and specificity were obtained at various point cutoffs and area under the receiver operator characteristic curve (AuROC) was determined to confirm the prediction power of the model.
Results.
Of the total 384 E.
coli strains tested, 212 (55.2%) produced ESBL.
The majority of these isolates were from urine (44.3%).
Carbapenems (>80%) and amikacin (89.6%) had good activity against ESBL producing E.
coli.
Eleven variables were identified as independent risk factors for ESBL producing E.
coli infection including Enterobacteriaceae colonization or infection in preceding year (OR=8.15, 95%CI 5.12–21.71), daily prednisone dose > 30mg (OR=5.48, 95%CI 3.12–13.72), low C3 levels (OR=2.17, 95%CI 1.62–6.71), nosocomial acquired infection (OR=4.12, 95%CI 1.98–8.85), etc.
The model developed to predict ESBL producing E.
coli infection was effective, with the AuROC of 0.840 (95% CI 0.799-0.876).
Conclusions.
The prevalence of ESBL producing E.
coli was increasing with high antibiotics resistance in patients with SLE.
The model revealed excellent predictive performance and exhibited a good discrimination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Yuetian& Shen, Hui& Zhu, Cheng& Guo, Ruru& Gao, Yuan& Lu, Liangjing. 2018. Infections Caused by Extended-Spectrum β-Lactamase Producing Escherichia Coli in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Yuetian…[et al.]. Infections Caused by Extended-Spectrum β-Lactamase Producing Escherichia Coli in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Yuetian& Shen, Hui& Zhu, Cheng& Guo, Ruru& Gao, Yuan& Lu, Liangjing. Infections Caused by Extended-Spectrum β-Lactamase Producing Escherichia Coli in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر