Prognostic Significance of P16INK4a Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis
المؤلفون المشاركون
Zhang, Jiayi
Zhang, Hengcheng
Xiu, Yanyan
Cheng, Hong
Gu, Min
Song, Ninghong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Recently, P16INK4a expression has been shown to be correlated with cancer-specific survival (CSS) in penile squamous cell carcinoma (SCC).
Therefore, we performed this meta-analysis to clarify the prognostic value of P16INK4a for penile SCC.
Methods.
A systematic search was performed in PubMed, Embase, and Web of Science to identify all relevant articles up to May 25, 2017.
Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of included studies were pooled to estimate the prognostic value.
Trial sequential analysis (TSA) was performed to assess the quantity and strength of survival evidence.
Results.
Five retrospective studies consisting of 323 cases were finally included.
We found that P16INK4a positive expression was significantly associated with a better CSS of penile SCC (HR=0.45, 95%CI: 0.30-0.67, P<0.001).
No heterogeneity or publication bias was noted among the included studies.
Furthermore, TSA demonstrated that the findings were based on sufficient evidence.
Conclusions.
P16INK4a positive expression is independently associated with improved CSS for patients with penile SCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jiayi& Zhang, Hengcheng& Xiu, Yanyan& Cheng, Hong& Gu, Min& Song, Ninghong. 2018. Prognostic Significance of P16INK4a Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jiayi…[et al.]. Prognostic Significance of P16INK4a Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jiayi& Zhang, Hengcheng& Xiu, Yanyan& Cheng, Hong& Gu, Min& Song, Ninghong. Prognostic Significance of P16INK4a Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر