Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis
المؤلفون المشاركون
Chen, Da-Qiu
Kong, Xiang-Sheng
Shen, Xue-Bin
Huang, Mao-Zhi
Zheng, Jian-Ping
Sun, Jing
Xu, Shang-Hua
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Acute myocardial infarction (AMI) is a common disease with high morbidity and mortality around the world.
The aim of this research was to determine the differentially expressed genes (DEGs), which may serve as potential therapeutic targets or new biomarkers in AMI.
Methods.
From the Gene Expression Omnibus (GEO) database, three gene expression profiles (GSE775, GSE19322, and GSE97494) were downloaded.
To identify the DEGs, integrated bioinformatics analysis and robust rank aggregation (RRA) method were applied.
These DEGs were performed through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses by using Clusterprofiler package.
In order to explore the correlation between these DEGs, the interaction network of protein-protein internet (PPI) was constructed using the STRING database.
Utilizing the MCODE plug-in of Cytoscape, the module analysis was performed.
Utilizing the cytoHubba plug-in, the hub genes were screened out.
Results.
57 DEGs in total were identified, including 2 down- and 55 upregulated genes.
These DEGs were mainly enriched in cytokine-cytokine receptor interaction, chemokine signaling pathway, TNF signaling pathway, and so on.
The module analysis filtered out 18 key genes, including Cxcl5, Arg1, Cxcl1, Spp1, Selp, Ptx3, Tnfaip6, Mmp8, Serpine1, Ptgs2, Il6, Il1r2, Il1b, Ccl3, Ccr1, Hmox1, Cxcl2, and Ccl2.
Ccr1 was the most fundamental gene in PPI network.
4 hub genes in total were identified, including Cxcl1, Cxcl2, Cxcl5, and Mmp8.
Conclusion.
This study may provide credible molecular biomarkers in terms of screening, diagnosis, and prognosis for AMI.
Meanwhile, it also serves as a basis for exploring new therapeutic target for AMI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Da-Qiu& Kong, Xiang-Sheng& Shen, Xue-Bin& Huang, Mao-Zhi& Zheng, Jian-Ping& Sun, Jing…[et al.]. 2019. Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis. Cardiovascular Therapeutics،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1129188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Da-Qiu…[et al.]. Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis. Cardiovascular Therapeutics No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1129188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Da-Qiu& Kong, Xiang-Sheng& Shen, Xue-Bin& Huang, Mao-Zhi& Zheng, Jian-Ping& Sun, Jing…[et al.]. Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis. Cardiovascular Therapeutics. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1129188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر