Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer’s Disease
المؤلفون المشاركون
Chang, Ya-Ting
Huang, Chi-Wei
Lee, Jun-Jun
Chang, Chiung-Chih
Chang, Wen-Neng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
We aimed to investigate how altered intrinsic connectivity networks (ICNs) affect pathologic changes of Alzheimer’s disease (AD) at a network-based level.
Methods.
Thirty normal controls (NCs), 23 patients with AD-mild cognitive impairment (MCI), and 20 patients with AD-dementia were enrolled.
We compared the organization of grey matter structural covariance and functional connectivity in ICNs between NCs and all AD patients who were amyloid β (Aβ)-positive.
We further used seed-based interregional covariance analysis to compare structural and Aβ plaque covariance in default mode network (DMN) between AD-MCI and AD-dementia groups.
Results.
The patients with AD had increased functional interregional covariance among the regions of the ICN anchored to dorsal caudate (DC) seeds compared to the NCs.
The increased connectivity was associated with extended patterns of reduced Aβ plaque covariance in the AD-dementia group compared to the AD-MCI group within the striatal network anchored to DC seeds.
Patterns of lower Aβ plaque covariance in the AD-dementia group compared to the AD-MCI group were more extended within the network anchored to DC seeds than within the DMN, which was undergoing functional failure in the patients with AD.
Significant decreased structural covariance in the AD-dementia group compared to the AD-MCI group was more extended in the DMN during functional failure.
Conclusions.
Functional connectivity in ICNs affects the topographic spread of molecular pathologies.
The temporal trajectory of pathologic alterations can be well demonstrated by pathologic covariance comparisons between different clinical stages.
Pathologic covariance can provide critical support to pathologic interactions at network and molecular levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Ya-Ting& Huang, Chi-Wei& Chang, Wen-Neng& Lee, Jun-Jun& Chang, Chiung-Chih. 2018. Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Ya-Ting…[et al.]. Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer’s Disease. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1129229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Ya-Ting& Huang, Chi-Wei& Chang, Wen-Neng& Lee, Jun-Jun& Chang, Chiung-Chih. Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر