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Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study
المؤلفون المشاركون
Oh, Seung Ha
Kim, So Young
Heo, Hwon
Kim, Doo Hee
Kim, Hyun Jin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Single-sided deafness (SSD) induces cortical neural plastic changes according to duration of deafness.
However, it is still unclear how the auditory cortical changes accompany the subcortical neural changes.
The present study aimed to find the neural plastic changes in the cortical and subcortical auditory system following adult-onset single-sided deafness (SSD) using Mn-enhanced magnetic resonance imaging (MEMRI).
B57BL/6 mice (postnatal 8-week-old) were divided into three groups: the SSD-4-week group (postnatal 12-week-old, n = 11), the SSD-8-week group (postnatal 16-week-old, n = 11), and a normal-hearing control group (postnatal 8-week-old, n = 9).
The left cochlea was ablated in the SSD groups.
White Gaussian noise was delivered for 24 h before MEMRI acquisition.
T1-weighted MRI data were analyzed from the cochlear nucleus (CN), superior olivary complex (SOC), lateral lemniscus (LL), inferior colliculus (IC), medial geniculate body (MG), and auditory cortex (AC).
The differences in relative Mn2+-enhanced signal intensities (Mn2+SI) and laterality were analyzed between the groups.
Four weeks after the SSD procedure, the ipsilateral side of the SSD showed significantly lower Mn2+SI in the CN than the control group.
On the other hand, the contralateral side of the SSD demonstrated significantly lower Mn2+SI in the SOC, LL, and IC.
These decreased Mn2+SI values were partially recovered at 8 weeks after the SSD procedure.
The interaural Mn2+SI differences representing the interaural dominance were highest in CN and then became less prominently higher in the auditory neural system.
The SSD-8-week group still showed interaural differences in the CN, LL, and IC.
In contrast, the MG and AC did not show any significant intergroup or interaural differences in Mn2+SI.
In conclusion, subcortical auditory neural activities were decreased after SSD, and the interaural differences were diluted in the higher auditory nervous system.
These findings were attenuated with time.
Subcortical auditory neural changes after SSD may contribute to the change in tinnitus severity and the outcomes of cochlear implantation in SSD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, So Young& Heo, Hwon& Kim, Doo Hee& Kim, Hyun Jin& Oh, Seung Ha. 2018. Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129252
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, So Young…[et al.]. Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129252
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, So Young& Heo, Hwon& Kim, Doo Hee& Kim, Hyun Jin& Oh, Seung Ha. Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129252
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129252
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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