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Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
المؤلفون المشاركون
Saad, Marwan
Mando, Ramy
Goel, Akshay
Habash, Fuad
Ayoub, Karam
Vallurupalli, Srikanth
Maskoun, Waddah
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Cardiac contractility modulation (CCM) is a device therapy for systolic heart failure (HF) in patients with narrow QRS.
We aimed to perform an updated meta-analysis of the randomized clinical trials (RCTs) to assess the efficacy and safety of CCM therapy.
Methods.
We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) between January 2001 and June 2018.
Outcomes of interest were peak oxygen consumption (peak VO2), 6-Minute Walk Distance (6MWD), Minnesota Living with Heart Failure Questionnaire (MLHFQ), HF hospitalizations, cardiac arrhythmias, pacemaker/ICD malfunctioning, all-cause hospitalizations, and mortality.
Data were expressed as standardized mean difference (SMD) or odds ratio (OR).
Results.
Four RCTs including 801 patients (CCM n = 394) were available for analysis.
The mean age was 59.63 ± 0.84 years, mean ejection fraction was 29.14 ± 1.22%, and mean QRS duration was 106.23 ± 1.65 msec.
Mean follow-up duration was six months.
CCM was associated with improved MLWHFQ (SMD -0.69, p = 0.0008).
There were no differences in HF hospitalizations (OR 0.76, p = 0.12), 6MWD (SMD 0.67, p = 0.10), arrhythmias (OR 1.40, p = 0.14), pacemaker/ICD malfunction/sensing defect (OR 2.23, p = 0.06), all-cause hospitalizations (OR 0.73, p = 0.33), or all-cause mortality (OR 1.04, p = 0.92) between the CCM and non-CCM groups.
Conclusions.
Short-term treatment with CCM may improve MLFHQ without significant difference in 6MWD, arrhythmic events, HF hospitalizations, all-cause hospitalizations, and all-cause mortality.
There is a trend towards increased pacemaker/ICD device malfunction.
Larger RCTs might be needed to determine if the CCM therapy will be beneficial with longer follow-up.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mando, Ramy& Goel, Akshay& Habash, Fuad& Saad, Marwan& Ayoub, Karam& Vallurupalli, Srikanth…[et al.]. 2019. Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Cardiovascular Therapeutics،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1129253
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mando, Ramy…[et al.]. Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Cardiovascular Therapeutics No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1129253
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mando, Ramy& Goel, Akshay& Habash, Fuad& Saad, Marwan& Ayoub, Karam& Vallurupalli, Srikanth…[et al.]. Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Cardiovascular Therapeutics. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1129253
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129253
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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