Antidiabetic and Antiobesity Effects of Artemether in dbdb Mice
المؤلفون المشاركون
Guo, Yu
Fu, Wei
Xin, Yakai
Bai, Jinlei
Peng, Huifang
Fu, Liujun
Liu, Jie
Li, Liping
Ma, Yujin
Jiang, Hongwei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study is designed to investigate the effect of artemether on type 2 diabetic db/db mice.
The experiments consisted of three groups: normal control (NC, db/+, 1% methylcellulose, intragastric administration), diabetic control (DM, db/db, 1% methylcellulose, intragastric administration), and artemether treated (artemether, db/db, 200 mg/kg of artemether, intragastric administration).
The treatment lasted for two weeks.
The food intake, body weight, and fasting blood glucose of mice were measured every three days.
At the start and end of the experiment, the intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (IPITT) were performed.
We determined the serum insulin and glucagon levels by ELISA kits and calculated insulin resistance index (HOME-IR).
HE staining was used to observe the morphologies of pancreas and liver in mice.
The damage of pancreatic beta cells was evaluated by TUNEL staining and immunofluorescence.
We found the following: (1) compared with the DM group, the food intake and weight increase rate of artemether group significantly reduced ( P < 0.05 ); (2) compared with pretreatment, artemether significantly reduced the fasting blood glucose levels, and the areas under the curves (AUCs) of IPGTT were decreased significantly, increasing the tolerance to glucose of db/db mice.
( P < 0.05 ); (3) artemether improved hyperinsulinemia and decreased the AUCs of IPITT and HOME-IR, increasing the insulin sensitivity of db/db mice.
(4) Artemether significantly ameliorated islet vacuolar degeneration and hepatic steatosis in db/db mice.
(5) Artemether reduced the apoptosis of pancreatic beta cells and increased insulin secretion in db/db mice compared with DM group ( P < 0.05 ).
Our results indicated that artemether significantly improved glucose homeostasis and insulin resistance and had the potential activity to prevent obesity, reduced the severity of fatty liver, and protected pancreatic beta cells, promising to treat type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Yu& Fu, Wei& Xin, Yakai& Bai, Jinlei& Peng, Huifang& Fu, Liujun…[et al.]. 2018. Antidiabetic and Antiobesity Effects of Artemether in dbdb Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129276
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Yu…[et al.]. Antidiabetic and Antiobesity Effects of Artemether in dbdb Mice. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129276
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Yu& Fu, Wei& Xin, Yakai& Bai, Jinlei& Peng, Huifang& Fu, Liujun…[et al.]. Antidiabetic and Antiobesity Effects of Artemether in dbdb Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129276
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129276
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر