Thoracic Organ Doses and Cancer Risk from Low Pitch Helical 4-Dimensional Computed Tomography Scans

المؤلفون المشاركون

Feng, Yuanming
Yang, Chengwen
Liu, Ransheng
Ming, Xin
Liu, Ningbo
Guan, Yong

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-09-24

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Purpose.

To investigate the dose depositions to organs at risk (OARs) and associated cancer risk in cancer patients scanned with 4-dimensional computed tomography (4DCT) as compared with conventional 3DCT.

Methods and Materials.

The radiotherapy treatment planning CT image and structure sets of 102 patients were converted to CT phantoms.

The effective diameters of those patients were computed.

Thoracic scan protocols in 4DCT and 3DCT were simulated and verified with a validated Monte Carlo code.

The doses to OARs (heart, lungs, esophagus, trachea, spinal cord, and skin) were calculated and their correlations with patient effective diameter were investigated.

The associated cancer risk was calculated using the published models in BEIR VII reports.

Results.

The average of mean dose to thoracic organs was in the range of 7.82-11.84 cGy per 4DCT scan and 0.64-0.85 cGy per 3DCT scan.

The average dose delivered per 4DCT scan was 12.8-fold higher than that of 3DCT scan.

The organ dose was linearly decreased as the function of patients’ effective diameter.

The ranges of intercept and slope of the linear function were 17.17-30.95 and -0.0278--0.0576 among patients’ 4DCT scans, and 1.63-2.43 and -0.003--0.0045 among patients’ 3DCT scans.

Relative risk of cancer increased (with a ratio of 15.68:1) resulting from 4DCT scans as compared to 3DCT scans.

Conclusions.

As compared to 3DCT, 4DCT scans deliver more organ doses, especially for pediatric patients.

Substantial increase in lung cancer risk is associated with higher radiation dose from 4DCT and smaller patients’ size as well as younger age.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yang, Chengwen& Liu, Ransheng& Ming, Xin& Liu, Ningbo& Guan, Yong& Feng, Yuanming. 2018. Thoracic Organ Doses and Cancer Risk from Low Pitch Helical 4-Dimensional Computed Tomography Scans. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129382

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yang, Chengwen…[et al.]. Thoracic Organ Doses and Cancer Risk from Low Pitch Helical 4-Dimensional Computed Tomography Scans. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129382

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yang, Chengwen& Liu, Ransheng& Ming, Xin& Liu, Ningbo& Guan, Yong& Feng, Yuanming. Thoracic Organ Doses and Cancer Risk from Low Pitch Helical 4-Dimensional Computed Tomography Scans. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129382

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1129382