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Adoptive Transfers of CD4+CD25+ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis
المؤلفون المشاركون
Wang, Kai
Hu, Gui-Xue
Zhu, Tongjia
Wang, Haijun
Yang, Jinxin
Du, Shuaishuai
Dong, Guoying
Pei, Zhihua
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
CD4+CD25+Foxp3+ Tregs control the immune response and maintain immune homeostasis.
This study examined whether Tregs can affect mouse enteritis and the Foxp3 (Forkhead transcription factor) transcriptional pathway.
Mouse CD4+CD25+ Treg cells were labelled using CFSE (5,6-carboxyfluorescein diacetate succinimidyl ester) and transferred to enteritis model mice.
The mice were randomly divided into an enteritis group, a Treg-infusion group, a Treg-inhibiting group, and a control group.
Histopathology, ELISA, flow cytometry, western blot, immunohistochemistry, and immunofluorescence were performed.
Our results demonstrated that CD4+CD25+ Tregs were successfully transferred.
The disease activity index (DAI) scores in the Tregs-infusion group were lower than those of the enteritis and Tregs-inhibiting groups.
The number of goblet cells and inflammatory cells was reduced, and the levels of IL-1β, TNF-α, NO, and PGE2 were significantly decreased in the Tregs-infusion group compared to those in the enteritis group (p<0.05).
The number of CD4+CD25+Foxp3+ Tregs and CD4+IL-17A+ Th17 cells in the mesenteric lymph nodes differed significantly from the enteritis and Tregs-inhibiting groups (p<0.05).
There were more Foxp3+ Tregs and Smad3 and NFAT2 infiltrated into the duodenum after adoptive transfer of CD4+CD25+ Tregs, which was a significant difference relative to the enteritis group (p<0.05).
This study demonstrated that adoptive transfer of CD4+CD25+ Tregs can decrease mouse enteritis.
Foxp3 expression may be improved through the Smad3 and NFAT2 signalling pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Kai& Zhu, Tongjia& Wang, Haijun& Yang, Jinxin& Du, Shuaishuai& Dong, Guoying…[et al.]. 2018. Adoptive Transfers of CD4+CD25+ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129472
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Kai…[et al.]. Adoptive Transfers of CD4+CD25+ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129472
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Kai& Zhu, Tongjia& Wang, Haijun& Yang, Jinxin& Du, Shuaishuai& Dong, Guoying…[et al.]. Adoptive Transfers of CD4+CD25+ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129472
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129472
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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