Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy
المؤلفون المشاركون
Lin, Wei-Che
Li, Shau-Hsuan
Wang, Yu-Ming
Lu, Hung-I
Chiu, Tai-Jan
Chen, Chang-Han
Huang, Wan-Ting
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
The osteopontin has been involved in therapeutic resistance in a variety of cancers.
But, the significance of osteopontin expression on the prognosis of patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving chemoradiotherapy is unclear.
Methods.
In 80 patients with locally advanced ESCC receiving preoperative chemoradiotherapy between 1999 and 2012, osteopontin expression was evaluated by immunohistochemistry and correlated with treatment outcome.
The functional role of osteopontin in ESCC cell lines was determined by osteopontin-mediated siRNA.
Results.
Osteopontin expression and clinical T4 classification were significantly associated with poor pathological complete response.
Univariate analyses demonstrated that osteopontin overexpression and clinical T classification, T4, were significantly associated with worse overall survival and disease-free survival.
In multivariate comparison, osteopontin overexpression and clinical T classification, T4, represented the independent adverse prognosticator.
In ESCC cell lines, endogenous osteopontin depletion by osteopontin-mediated siRNA increased sensitivity to cisplatin.
Osteopontin expression is independently correlated with the response of chemoradiotherapy and prognosis of patients with locally advanced ESCC receiving preoperative chemoradiotherapy.
Conclusions.
Our results suggest that osteopontin may be a potential therapeutic target for patients with ESCC treated with preoperative chemoradiotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chiu, Tai-Jan& Lu, Hung-I& Chen, Chang-Han& Huang, Wan-Ting& Wang, Yu-Ming& Lin, Wei-Che…[et al.]. 2018. Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chiu, Tai-Jan…[et al.]. Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chiu, Tai-Jan& Lu, Hung-I& Chen, Chang-Han& Huang, Wan-Ting& Wang, Yu-Ming& Lin, Wei-Che…[et al.]. Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر