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Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model
المؤلفون المشاركون
Lee, Jae-Hun
Lee, Min Young
Chung, Phil-Sang
Jung, Jae Yun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hair cells in the cochlea can be damaged by various causes.
Damaged hair cells can lead to additional destruction of parts of the auditory afferent pathway sequentially, which is called secondary degeneration.
Recently, researches regarding cochlear implants have been actively carried out for clinical purposes; secondary degeneration in animals is a much more practical model for identifying the prognosis of cochlear implants.
However, an appropriate model for this research is not established yet.
Thus, we developed a secondary degeneration model using an ototoxic drug.
35 gerbils were separated into four different groups and kanamycin was applied via various approaches.
ABR was measured several times after drug administration.
SGCs were also counted to identify any secondary degeneration.
The results showed that outer and inner HCs were damaged in all kanamycin-treated groups.
Twelve weeks after kanamycin treatment, the round window membrane injection group showed severe subject differences in hair cells and SGC damage, whereas the gelfoam group showed consistent and severe damage in hair cells and SGCs.
In this study, we successfully induced secondary degeneration in hair cells in a gerbil model.
This model can be used for various purposes in the hearing research area either for treatment or for preservation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Jae-Hun& Lee, Min Young& Chung, Phil-Sang& Jung, Jae Yun. 2018. Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129535
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Jae-Hun…[et al.]. Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129535
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Jae-Hun& Lee, Min Young& Chung, Phil-Sang& Jung, Jae Yun. Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129535
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129535
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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