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Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair
المؤلفون المشاركون
Perroteau, Isabelle
Tos, Pierluigi
Gambarotta, Giovanna
Battiston, Bruno
Fornasari, Benedetta Elena
Crosio, Alessandro
Budau, Claudia Alexandra
Geuna, Stefano
Raimondo, Stefania
Ronchi, Giulia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Muscle-in-vein conduit is successfully employed for repairing nerve injuries: the vein prevents muscle fiber dispersion, while the muscle prevents the vein collapse and creates a favorable environment for Schwann cell migration and axon regrowth.
However, it requires microsurgical skills.
In this study we show a simple strategy to improve the performance of a chitosan hollow tube by the introduction of fresh skeletal muscle fibers.
The hypothesis is to overcome the technical issue of the muscle-in-vein preparation and to take advantage of fiber muscle properties to create an easy and effective conduit for nerve regeneration.
Rat median nerve gaps were repaired with chitosan tubes filled with skeletal muscle fibers (muscle-in-tube graft), hollow chitosan tubes, or autologous nerve grafts.
Our results demonstrate that the fresh skeletal muscle inside the conduit is an endogenous source of soluble Neuregulin 1, a key factor for Schwann cell survival and dedifferentiation, absent in the hollow tube during the early phase of regeneration.
However, nerve regeneration assessed at late time point was similar to that obtained with the hollow tube.
To conclude, the muscle-in-tube graft is surgically easy to perform and we suggest that it might be a promising strategy to repair longer nerve gap or for secondary nerve repair, situations in which Schwann cell atrophy is a limiting factor for recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ronchi, Giulia& Fornasari, Benedetta Elena& Crosio, Alessandro& Budau, Claudia Alexandra& Tos, Pierluigi& Perroteau, Isabelle…[et al.]. 2018. Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1129553
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ronchi, Giulia…[et al.]. Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1129553
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ronchi, Giulia& Fornasari, Benedetta Elena& Crosio, Alessandro& Budau, Claudia Alexandra& Tos, Pierluigi& Perroteau, Isabelle…[et al.]. Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1129553
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129553
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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