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The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health
المؤلفون المشاركون
Feller, Liviu
Fourie, J.
Lemmer, J.
Motswaledi, M. H.
Ballyram, R.
Khammissa, Razia A. G.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Vitamin D plays an important role in calcium homeostasis and bone metabolism, with the capacity to modulate innate and adaptive immune function, cardiovascular function, and proliferation and differentiation of both normal and malignant keratinocytes.
1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR).
Upon stimulation by 1,25(OH)2D, VDR forms a heterodimer with the retinoid X receptor (RXR).
In turn, VDR/RXR binds to DNA sequences termed vitamin D response elements in target genes, regulating gene transcription.
In order to exert its biological effects, VDR signalling interacts with other intracellular signalling pathways.
In some cases 1,25(OH)2D exerts its biological effects without regulating either gene expression or protein synthesis.
Although the regulatory role of vitamin D in many biological processes is well documented, there is not enough evidence to support the therapeutic use of vitamin D supplementation in the prevention or treatment of infectious, immunoinflammatory, or hyperproliferative disorders.
In this review we highlight the effects of 1,25(OH)2D on bone and calcium homeostasis, on cancer, and refer to its effects on the cardiovascular and immune systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khammissa, Razia A. G.& Fourie, J.& Motswaledi, M. H.& Ballyram, R.& Lemmer, J.& Feller, Liviu. 2018. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129647
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khammissa, Razia A. G.…[et al.]. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129647
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khammissa, Razia A. G.& Fourie, J.& Motswaledi, M. H.& Ballyram, R.& Lemmer, J.& Feller, Liviu. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129647
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129647
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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