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Evidence for Seroprevalence in Human Localized Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka
المؤلفون المشاركون
Siriwardana, Yamuna
Deepachandi, Bhagya
Karunaweera, Nadira D.
Ranasinghe, Samantha
Soysa, Preethi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Visceral leishmaniasis (VL) is considered as a major health threat in the Indian subcontinent.
Leishmania donovani, a usually visceralizing species, causes cutaneous leishmaniasis (CL) in Sri Lanka.
However, visceralizing potential of the local L.
donovani is not yet fully understood.
This project studied the seroprevalence of local CL by using an in-house ELISA.
An IgG-based ELISA using crude Leishmania antigen (Ag) was developed and validated.
A total of 50 laboratory confirmed cases of locally acquired CL were examined using the newly developed ELISA.
According to the optimized ELISA, seroprevalence of anti-Leishmania IgG antibodies in the study group was 34.0% (n=17/50).
Majority of seropositive individuals were males (n=13/17), representing 76%.
Nearly half of the seropositive individuals were young adults (20–40 years, n=9/17, 53%).
Higher proportions of single lesions, large lesions, and nodular lesions were associated with a seroconversion.
A proportion of local L.
donovani infections leading to CL have the ability to raise an antibody response in the host.
This may indicate early systemic involvement as one possibility.
Study of a large number of patients with adequate follow-up would be useful.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siriwardana, Yamuna& Deepachandi, Bhagya& Ranasinghe, Samantha& Soysa, Preethi& Karunaweera, Nadira D.. 2018. Evidence for Seroprevalence in Human Localized Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1129665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siriwardana, Yamuna…[et al.]. Evidence for Seroprevalence in Human Localized Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1129665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siriwardana, Yamuna& Deepachandi, Bhagya& Ranasinghe, Samantha& Soysa, Preethi& Karunaweera, Nadira D.. Evidence for Seroprevalence in Human Localized Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1129665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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