Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3
المؤلفون المشاركون
Romuk, Ewa
Niedziela, Natalia
Adamczyk-Sowa, Monika
Niedziela, Jacek T.
Pierzchała, Krystyna
Zalejska-Fiolka, Jolanta
Torbus-Paluszczak, Magdalena
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
In addition to the widely known effect of vitamin D3 (vitD3) on the skeleton, its role in the regulation of the immune response was also confirmed.
Aim.
The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D3.
Methods.
The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D3 deficiency (VitDd), insufficiency (VitDi), and normal vitamin D3 level (VitDn) subgroups.
Results.
The highest level of the parathyroid hormone (PTH) and the highest prevalence of hypophosphatemia and osteopenia were demonstrated in VitDd group compared to VitDi and VitDn.
However, in VitDd, VitDi, and VitDn subgroups no significant differences were observed in the levels of alkaline phosphatase (ALP) and ionized calcium (Ca2+) and in DXA indices.
A negative correlation was observed between the level of vitamin D3 and the Expanded Disability Status Scale (EDSS) in the whole MS group.
The subgroups were significantly different with respect to the EDSS scores and the frequency of complaints related to walking according to the EQ-5D.
Conclusions.
It is necessary to assess calcium-phosphate metabolism and supplementation of vitamin D3 in RRMS patients.
The higher the clinical stage of the disease assessed with the EDSS, the lower the level of vitamin D3 in blood serum.
Subjectively reported complaints related to difficulties with walking were reflected in the EDSS in VitDd patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Niedziela, Natalia& Pierzchała, Krystyna& Zalejska-Fiolka, Jolanta& Niedziela, Jacek T.& Romuk, Ewa& Torbus-Paluszczak, Magdalena…[et al.]. 2018. Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Niedziela, Natalia…[et al.]. Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Niedziela, Natalia& Pierzchała, Krystyna& Zalejska-Fiolka, Jolanta& Niedziela, Jacek T.& Romuk, Ewa& Torbus-Paluszczak, Magdalena…[et al.]. Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر