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Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis
المؤلفون المشاركون
Rahmani, Mahboubeh
Halene, Stephanie
Xu, Mina L.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Context.
Intravascular large B-cell lymphoma (IVLBCL) is a rare non-Hodgkin B-cell lymphoma with a poor prognosis.
While typically described as comprising large atypical cells restricted to the lumina of small blood vessels, it can show variability in cell size.
Objective.
To report the clinicopathologic features of the IVLBCL with small cell morphology and discuss the practical implications of our findings.
Design.
We searched our archives for all IVLBCL diagnosed in our institution for the last 25 years (1992–2017).
Slides were reviewed independently by two hematopathologists.
Results.
We found a total of 11 cases of IVLBCL.
Bone marrow, brain, lymph node, pericardium, small bowel, and fallopian tube and ovary were the organs in which the lymphoma was initially diagnosed.
One of the cases initially diagnosed in the marrow showed intrasinusoidal involvement by a small cell lymphoma; the diagnosis was confirmed by random skin biopsies showing intravascular large cells with the same phenotype.
Retrospective review of the liver on this case also showed the intrasinusoidal involvement by the disease consisting of small cells.
In another case, IVLBCL that was initially diagnosed in a small bowel biopsy was retrospectively found in a breast biopsy, but with small cell morphology.
Conclusions.
Our findings suggest that, in the presence of high clinical suspicion, IVLBCL should be high in the differential diagnosis when lymphoma is predominantly intravascular, even when the tumor cells are small.
A timely diagnosis of this entity can be critical.
Hence, awareness of a small cell variant of IVLBCL should be increased.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahmani, Mahboubeh& Halene, Stephanie& Xu, Mina L.. 2018. Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129717
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahmani, Mahboubeh…[et al.]. Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129717
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahmani, Mahboubeh& Halene, Stephanie& Xu, Mina L.. Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129717
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129717
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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