Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy
المؤلفون المشاركون
Mazur, Włodzimierz
Simon, Krzysztof
Zarębska-Michaluk, Dorota
Buczyńska, Iwona
Tudrujek-Zdunek, Magdalena
Janczewska, Ewa
Dybowska, Dorota
Sitko, Marek
Dobracka, Beata
Jaroszewicz, Jerzy
Pabjan, Paweł
Klapaczyński, Jakub
Laurans, Łukasz
Socha, Łukasz
Tronina, Olga
Parczewski, Miłosz
Flisiak, Robert
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Aim.
The development of interferon- (IFN-) free regimens substantially improved efficacy of treatment for HCV, but despite excellent effectiveness the failures still occur.
The aim of our study was to evaluate the efficacy of retreatment with genotype specific direct acting antivirals- (DAA-) based regimens in nonresponders to previous IFN-free therapy.
Materials and Methods.
Analysed population consisted of 31 nonresponders to IFN-free regimen, which received second IFN-free rescue therapy, selected from 6228 patients included in a national database EpiTer-2.
Results.
Age and gender distribution were similar, whereas proportion of genotype 1b was slightly higher and genotype 4 lower in the whole population compared to studied one.
Patients included in the study demonstrated much more advanced fibrosis.
Primary therapy was discontinued in 12 patients, which were recognized as failures due to nonvirologic reason, whereas virologic reason of therapeutic failure was recognized in 19 patients which completed therapy.
Overall sustained virologic response (SVR) rate was 81% and 86% in intent-to-treat (ITT) and modified ITT analysis, respectively (74% and 78% in virologic failures, 92% and 100% in nonvirologic failures).
Resistance-associated substitutions (RAS) testing was carried out in 8 patients from the group of completed primary therapy and three of them had potential risk for failure of rescue therapy due to NS5A association, while two of them achieved SVR.
Conclusions.
We demonstrated moderate effectiveness of genotype specific rescue therapy in failures due to virologic reason and high in those who discontinued primary therapy.
Therefore rescue therapy with genotype specific regimens should be considered always if more potent regimens are not available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zarębska-Michaluk, Dorota& Buczyńska, Iwona& Simon, Krzysztof& Tudrujek-Zdunek, Magdalena& Janczewska, Ewa& Dybowska, Dorota…[et al.]. 2019. Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1129837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zarębska-Michaluk, Dorota…[et al.]. Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1129837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zarębska-Michaluk, Dorota& Buczyńska, Iwona& Simon, Krzysztof& Tudrujek-Zdunek, Magdalena& Janczewska, Ewa& Dybowska, Dorota…[et al.]. Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1129837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر