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Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis
المؤلفون المشاركون
Yan, Zhiqiang
Yang, Fang
Hong, Zhu
Wang, Shishun
Jinjuan, Zhang
Han, Bing
Xie, Rujia
Leng, Feiyun
Yang, Qin
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Recently, blueberry has been identified as a candidate for the treatment of liver fibrosis.
Given the role of gut-liver axis in liver fibrosis and the importance of the gut microbiota homeostasis to the maintenance of the intestinal epithelial barrier, this study aimed to investigate whether blueberry could attenuate liver fibrosis and protect the intestinal epithelial barrier by maintaining the homeostasis of the gut microbiota.
Method.
A CCl4-induced rat liver fibrosis model was used to detect the roles of blueberry in liver fibrosis and intestinal epithelial barrier.
The liver weight and body weight were measured, the liver function was monitored by ALT and AST activity, protein and mRNA were determined by western blot and RT-qPCR, and the gut microbiome was detected by Miseq.
Results.
The results showed that blueberry could reduce the rate of liver weight/body weight gain (p<0.05), ALT (p<0.01) and AST (p<0.05) activity, and the expression of collagen I (p<0.01), collagen IV (p<0.01), and α-SMA (p<0.01) expression in CCl4-induced rat liver.
CCl4 impaired the intestinal epithelial barrier and decreased the expression of the tight junction protein.
Blueberry restored the intestinal epithelial barrier and increased the expression of the tight junction protein.
The gut microbiota homeostasis was impaired by CCl4, but after treatment with blueberry, the intestinal flora returned to normal.
Conclusion.
Blueberry attenuated liver fibrosis, protected intestinal epithelial barrier, and maintained the homeostasis of the gut microbiota in a CCl4-induced injury rat model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Zhiqiang& Yang, Fang& Hong, Zhu& Wang, Shishun& Jinjuan, Zhang& Han, Bing…[et al.]. 2019. Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1129854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Zhiqiang…[et al.]. Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1129854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Zhiqiang& Yang, Fang& Hong, Zhu& Wang, Shishun& Jinjuan, Zhang& Han, Bing…[et al.]. Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1129854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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