Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation
المؤلفون المشاركون
Koehler, Michael
Schmidt, Hartmut
Bürger, Christin
Maschmeier, Miriam
Hüsing-Kabar, Anna
Wilms, Christian
Schmidt, Martina
Kabar, Iyad
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue.
Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies.
Methods.
All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study.
Database research was performed and a multivariable regression analysis was conducted to explore potential risk factors for HCC recurrence.
Results.
A total of 82 patients were eligible for the statistical analysis.
Independent of bridging strategy, achieving complete remission (CR) was significantly associated with a lower risk for tumor recurrence (p = 0.029; OR = 0.426, 95% CI 0.198-0.918).
A maximal diameter of lesion < 3 cm was also associated with lower recurrence rates (p = 0.040; OR = 0.140, 95% CI 0.022-0.914).
Vascular invasion proved to be an independent risk factor for HCC recurrence (p = 0.004; OR = 11.357, 95% CI 2.142-60.199).
Conclusion.
Achieving CR prior to LT results in a significant risk reduction of HCC recurrence after LT independent of the treatment modalities applied.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bürger, Christin& Maschmeier, Miriam& Hüsing-Kabar, Anna& Wilms, Christian& Koehler, Michael& Schmidt, Martina…[et al.]. 2019. Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bürger, Christin…[et al.]. Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1129873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bürger, Christin& Maschmeier, Miriam& Hüsing-Kabar, Anna& Wilms, Christian& Koehler, Michael& Schmidt, Martina…[et al.]. Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر