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High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls
المؤلفون المشاركون
Yu, Hong-Gui
Zhang, Hong-Qi
Zhou, Zhen-Hai
Wang, Yun-Jia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Adolescent idiopathic scoliosis (AIS) is common deformity with unknown cause.
Previous studies have suggested the abnormal serum leptin and ghrelin level in AIS girls.
The aim of present study was to evaluate whether the serum leptin and ghrelin level could serve as risk factor in predicting the curve progression in AIS girls.
The associations between them and the physical characteristics were also investigated.
Materials and Methods.
Circulating leptin and ghrelin levels from 105 AIS girls and 40 age-matched non-AIS girls were examined by enzyme-linked immunosorbent assay.
The correlations between ghrelin and leptin levels and growth-related parameters (age, weight, corrected height, corrected BMI, main Cobb angle, and Risser sign) were analyzed in AIS group.
Multivariate logistic regression was used to investigate factors predicting curve progression in AIS girls.
Results.
A significantly lower leptin level (6.55 ± 2.88 vs.
8.01 ± 3.12 ng/ml, p < 0.05) and a higher ghrelin level (6.33 ± 2.46 vs.
4.46 ± 2.02 ng/ml, p < 0.05) were found in all AIS patients, as compared with normal controls.
Curve progression patients had a higher ghrelin level than stable curve patients (7.61 ± 2.48 vs.
5.54 ± 2.11 ng/ml, p < 0.01); for leptin level, there was no significant difference between progression and stable group.
The results of multivariate logistic stepwise regression showed that premenarche status, initial main Cobb magnitude that was more than or equal to 23°, high ghrelin level (≥7.30 ng/ml), and lower Risser grade (grades 0 to 2) were identified as risk factors in predicting curve progression.
Ghrelin levels of >6.48 ng/ml were predictive for curve progression with 70.00 % sensitivity and 72.31 % specificity, and the area under the curve (AUC) was 0.741 (95 % confidence interval 0.646-0.821).
Conclusions.
High ghrelin level may serve as a new quantitative indicator for predicting curve progression in AIS girls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Hong-Gui& Zhang, Hong-Qi& Zhou, Zhen-Hai& Wang, Yun-Jia. 2018. High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Hong-Gui…[et al.]. High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Hong-Gui& Zhang, Hong-Qi& Zhou, Zhen-Hai& Wang, Yun-Jia. High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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