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Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer
المؤلفون المشاركون
Song, Yanfang
Huang, Zhengyuan
Kang, Yanli
Lin, Zhen
Lu, Pingxia
Lin, Qing
Cai, Zhaolian
Cao, Yingping
Zhu, Xianjin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Red blood cell distribution width (RDW) indicates the heterogeneity in the size of circulating red blood cells.
Increasing studies showed that RDW may be a diagnostic and prognostic marker in various tumors.
To investigate the value of RDW as a biomarker in the diagnosis and prognosis of colorectal cancer (CRC), we evaluated 783 newly diagnosed CRC patients, 463 colorectal adenomas (CA) patients, and 331 healthy controls from June 2015 to October 2017 at Fujian Medical University Union Hospital.
We found that RDW levels were significantly higher in CRC groups compared with both the CA and healthy control groups (P<0.001).
Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) for RDW, CEA, and CA19-9 was 0.643, 0.742, and 0.629 in discriminating CRC patients from healthy controls, respectively.
When RDW cut-off value of 13.95 was applied, we distinguished CRC patients from healthy controls with a sensitivity of 41% and a specificity of 94%.
Moreover, combined detection of RDW, CEA, and CA19-9 appeared to be a better diagnostic performance with a sensitivity of 56% and a specificity of 99%.
However, RDW had little diagnostic value in the differential diagnosis between CRC patients and CA patients.
More importantly, RDW levels were significantly associated with TNM stage, pT stage, pM stage, and tumor size among CRC patients.
Overall, our study suggested that RDW might be an auxiliary biomarker for diagnosis and prognosis of CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Yanfang& Huang, Zhengyuan& Kang, Yanli& Lin, Zhen& Lu, Pingxia& Lin, Qing…[et al.]. 2018. Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Yanfang…[et al.]. Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Yanfang& Huang, Zhengyuan& Kang, Yanli& Lin, Zhen& Lu, Pingxia& Lin, Qing…[et al.]. Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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