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Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI
المؤلفون المشاركون
Weikert, Thomas
Maas, Ole Christopher
Haas, Tanja
Klarhöfer, Markus
Bremerich, Jens
Forrer, Flavio
Sauter, Alexander Walter
Sommer, Gregor
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The purpose of this study was to determine if parameters derived from diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) can help to assess early response to peptide receptor radionuclide therapy (PRRT) with 90Y-DOTATOC in neuroendocrine hepatic metastases (NET-HM).
Twenty patients (10 male; 10 female; mean age: 59.2 years) with NET-HM were prospectively enrolled in this single-center imaging study.
DW-MRI and DCE-MRI studies were performed just before and 48 hours after therapy with 90Y-DOTATOC.
Abdominal SPECT/CT was performed 24 hours after therapy.
This MRI imaging and therapy session was repeated after a mean interval of 10 weeks.
Up to four lesions per patient were evaluated.
Response to therapy was evaluated using metastasis sizes at the first and second therapy session as standard for comparison (regressive, stable, and progressive).
DW-MRI analysis included the apparent diffusion coefficient (ADC) and parameters related to intravoxel incoherent motion (IVIM), namely, diffusion (D), perfusion fraction (f) and pseudo-diffusion (D∗).
DCE-MRI analysis comprised Ktrans, ve and kep.
For statistical analysis of group differences, one-way analysis of variance (ANOVA) and appropriate post hoc testing was performed.
A total of 51 lesions were evaluated.
Seven of 51 lesions (14%) showed size progression, 18/51 (35%) regression, and 26/51 (51%) remained stable.
The lesion-to-spleen uptake ratio in SPECT showed a decrease between the two treatment sessions that was significantly stronger in regressive lesions compared with stable (p=0.013) and progressive lesions (p=0.021).
ANOVA showed significant differences in mean ADC after 48 h (p=0.026), with higher ADC values for regressive lesions.
Regarding IVIM, highest values for D at baseline were seen in regressive lesions (p=0.023).
In DCE-MRI, a statistically significant increase in ve after 10 weeks (p=0.046) was found in regressive lesions.
No differences were observed for the transfer constants Ktrans and kep.
Diffusion restriction quantified as ADC was able to differentiate regressive from progressive NET-HMs as early as 48 hours after PRRT.
DW-MRI therefore may complement scintigraphy/SPECT for early assessment of response to PRRT.
Assessment of perfusion parameters using IVIM and DCE-MRI did not show an additional benefit.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weikert, Thomas& Maas, Ole Christopher& Haas, Tanja& Klarhöfer, Markus& Bremerich, Jens& Forrer, Flavio…[et al.]. 2019. Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weikert, Thomas…[et al.]. Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weikert, Thomas& Maas, Ole Christopher& Haas, Tanja& Klarhöfer, Markus& Bremerich, Jens& Forrer, Flavio…[et al.]. Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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