Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis
المؤلفون المشاركون
Monsurrò, Maria Rosaria
Trojsi, Francesca
Esposito, Fabrizio
Russo, Antonio
Santangelo, Gabriella
Tedeschi, Gioacchino
Femiano, Cinzia
Caiazzo, Giuseppina
Siciliano, Mattia
Passaniti, Carla
Bisecco, Alvino
Cirillo, Mario
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder.
Particularly, apathy has been reported to be associated with poor ALS prognosis.
However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated.
Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS.
Twenty-one consecutive ALS patients, in King’s clinical stage 1 or 2, and 19 age- and sex-matched healthy controls (HCs) underwent magnetic resonance imaging and neuropsychological examination.
Between-group comparisons did not show any significant difference on cognitive and behavioral variables.
When compared to HCs, ALS patients exhibited a decreased fractional anisotropy (FA) [p<.05, threshold-free cluster enhancement (TFCE) corrected] in the corpus callosum and in bilateral anterior cingulate cortices.
Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p<.05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes.
These results point towards an early microstructural degeneration of brain areas biologically involved in cognition and behavior regulation in ALS.
Moreover, the significant correlations between apathy and DTI measures in several brain areas may suggest that subtle WM changes may be associated with mild behavioral symptoms in ALS even in the absence of overt cognitive and behavioral impairment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Femiano, Cinzia& Trojsi, Francesca& Caiazzo, Giuseppina& Siciliano, Mattia& Passaniti, Carla& Russo, Antonio…[et al.]. 2018. Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Femiano, Cinzia…[et al.]. Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behavioural Neurology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Femiano, Cinzia& Trojsi, Francesca& Caiazzo, Giuseppina& Siciliano, Mattia& Passaniti, Carla& Russo, Antonio…[et al.]. Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر