Comparative Evaluation of 68Ga-Citrate PETCT and 18F-FDG PETCT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats
المؤلفون المشاركون
Wang, Zi
Cai, Liang
Xu, Tingting
Tang, Dan
Liu, Lin
Chen, Yue
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis.
RA is one of the most common disabling diseases in the clinic.
The main clinical intervention strategies are early diagnosis and early treatment.
This study aims to predict the diagnostic value of 68Ga-citrate and 18F-FDG PET/CT in RA by comparing and analyzing the value of 68Ga-citrate and 18F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats.
Some CIA models were established.
Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively.
The semiquantitative analysis of CIA rats was carried out with 68Ga-citrate PET/CT and 18F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUVmax) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed.
The distribution of CIA rats in vivo at the 68Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining.
68Ga-citrate PET/CT is obviously superior to 18F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant (P<0.001).
The uptake of these two radiopharmaceuticals showed the same trend in arthritis rats with different scores.
The distribution of 68Ga-citrate at 90 min is consistent with the trend shown by 68Ga-citrate PET/CT.
68Ga-citrate PET/CT can reflect the inflammatory activity of affected joints in CIA rats earlier and more sensitively than 18F-FDG PET/CT, and this imaging advantage continues until the later stage of inflammation.
Therefore, 68Ga-citrate PET/CT is worthy of further promotion and application in the clinical diagnosis of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zi& Cai, Liang& Xu, Tingting& Tang, Dan& Liu, Lin& Chen, Yue. 2019. Comparative Evaluation of 68Ga-Citrate PETCT and 18F-FDG PETCT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zi…[et al.]. Comparative Evaluation of 68Ga-Citrate PETCT and 18F-FDG PETCT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1130177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zi& Cai, Liang& Xu, Tingting& Tang, Dan& Liu, Lin& Chen, Yue. Comparative Evaluation of 68Ga-Citrate PETCT and 18F-FDG PETCT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر