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Xiao-Xu-Ming Decoction Reduced Mitophagy Activation and Improved Mitochondrial Function in Cerebral Ischemia and Reperfusion Injury
المؤلفون المشاركون
Lan, Rui
Zhang, Yong
Wu, Tao
Ma, Yun-Zhi
Wang, Bao-Qi
Zheng, Hai-Zhong
Li, Ya-Na
Wang, Yan
Gu, Chun-Qing
Wu, Ji-Tao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We investigated whether Xiao-Xu-Ming decoction reduced mitophagy activation and kept mitochondrial function in cerebral ischemia-reperfusion injury.
Rats were randomly divided into 5 groups: sham, ischemia and reperfusion (IR), IR plus XXMD (60 g/kg/day) (XXMD60), IR plus cyclosporin A (10 mg/kg/day) (CsA), and IR plus vehicle (Vehicle).
Focal cerebral ischemia and reperfusion models were induced by middle cerebral artery occlusion (MCAO).
Cerebral infarct areas were measured by triphenyl tetrazolium chloride staining.
Cerebral ischemic injury was evaluated by hematoxylin and eosin staining (HE) and Nissl staining.
Ultrastructural features of mitochondria and mitophagy in the penumbra of the ischemic cortex were observed by transmission electron microscopy.
Mitophagy was detected by immunofluorescence labeled with LC3B and VDAC1.
Autophagy lysosome formation was observed by immunofluorescence labeled with LC3B and Lamp1.
The expression of LC3B, Beclin1, and Lamp1 was analyzed by Western blot.
The rats subjected to MCAO showed worsened neurological score and cell ischemic damage.
These were all significantly reversed by XXMD or CsA.
Moreover, XXMD/CsA notably downregulated mitophagy and reduced the increase in LC3, Beclin1, and Lamp1 expression induced by cerebral ischemia and reperfusion.
The findings demonstrated that XXMD exerted neuroprotective effect via downregulating LC3, Beclin1, Lamp1, and mitochondrial p62 expression level, thus leading to the inhibition of mitophagy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lan, Rui& Zhang, Yong& Wu, Tao& Ma, Yun-Zhi& Wang, Bao-Qi& Zheng, Hai-Zhong…[et al.]. 2018. Xiao-Xu-Ming Decoction Reduced Mitophagy Activation and Improved Mitochondrial Function in Cerebral Ischemia and Reperfusion Injury. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1130183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lan, Rui…[et al.]. Xiao-Xu-Ming Decoction Reduced Mitophagy Activation and Improved Mitochondrial Function in Cerebral Ischemia and Reperfusion Injury. Behavioural Neurology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1130183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lan, Rui& Zhang, Yong& Wu, Tao& Ma, Yun-Zhi& Wang, Bao-Qi& Zheng, Hai-Zhong…[et al.]. Xiao-Xu-Ming Decoction Reduced Mitophagy Activation and Improved Mitochondrial Function in Cerebral Ischemia and Reperfusion Injury. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1130183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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