Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats
المؤلفون المشاركون
Zhou, Chunwu
Ma, Xiaohong
Wang, Shuang
Hu, Longbin
Feng, Shichao
Wu, Zhiyuan
Liu, Siyun
Duan, Shaofeng
Chen, Zhongwei
Zhao, Xinming
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Iron nanoparticles have an increasingly more and more important role in MR molecular imaging due to their novel magnetic and surface chemical properties.
They provide new possibilities for noninvasive diagnosis and treatment monitoring, especially for tissues that are rich in macrophages.
The smaller size and prolongation of the plasma half-life change the in vivo fate of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles captured by liver in reticuloendothelial system (RES) or mononuclear phagocytic system (MPS).
However, there is still a lack of MR imaging studies on the liver assessing USPIO nanoparticles <5 nm in size to reflect its absorption and clearance properties.
In this study, we used MRI to study the in vitro phantom and in vivo rat liver imaging characteristics of USPIO nanoparticles (<5 nm).
The results showed that USPIO nanoparticles (<5 nm) could potentially reduce longitudinal and transverse relaxation times and showed similar T1 relaxation rates compared with commercial gadolinium chelates.
In addition, USPIO nanoparticles (<5 nm) in vivo demonstrated both positive (T1) and negative (T2) liver contrast enhancement in healthy rats’ liver.
Furthermore, USPIO nanoparticles showed relatively good in vitro biocompatibility and fast clearance (within 45.17 minutes after intravenous injection) in the normal liver.
Taken together, these data might inspire a new personalized and precise diagnostic tool and stimulate new applications for specific targeted molecular probes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xiaohong& Wang, Shuang& Hu, Longbin& Feng, Shichao& Wu, Zhiyuan& Liu, Siyun…[et al.]. 2019. Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130232
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Xiaohong…[et al.]. Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1130232
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xiaohong& Wang, Shuang& Hu, Longbin& Feng, Shichao& Wu, Zhiyuan& Liu, Siyun…[et al.]. Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130232
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130232
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر