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Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid
المؤلفون المشاركون
Salonen, Jarno
Santos, Hélder A.
Mäkilä, Ermei
Jakobsson, Ulrika
Airaksinen, Anu J.
Alanen, Osku
Etilé, Asenath
Köster, Ulli
Ranjan, Sanjeev
Helariutta, Kerttuli
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Mesoporous silicon (PSi) is biocompatible and tailorable material with high potential in drug delivery applications.
Here, we report of an evaluation of PSi as a carrier platform for theranostics by delivering a radioactive ion beam- (RIB-) based radioactive lanthanoid into tumors in a mouse model of prostate carcinoma.
Thermally hydrocarbonized porous silicon (THCPSi) wafers were implanted with 159Dy at the facility for radioactive ion beams ISOLDE located at CERN, and the resulting [159Dy]THCPSi was postprocessed into particles.
The particles were intratumorally injected into mice bearing prostate cancer xenografts.
The stability of the particles was studied in vivo, followed by ex vivo biodistribution and autoradiographic studies.
We showed that the process of producing radionuclide-implanted PSi particles is feasible and that the [159Dy]THCPSi particles stay stable and local inside the tumor over seven days.
Upon release of 159Dy from the particles, the main site of accumulation is in the skeleton, which is in agreement with previous studies on the biodistribution of dysprosium.
We conclude that THCPSi particles are a suitable platform together with RIB-based radiolanthanoids for theranostic purposes as they are retained after administration inside the tumor and the radiolanthanoid remains embedded in the THCPSi.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jakobsson, Ulrika& Mäkilä, Ermei& Airaksinen, Anu J.& Alanen, Osku& Etilé, Asenath& Köster, Ulli…[et al.]. 2019. Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130235
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jakobsson, Ulrika…[et al.]. Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1130235
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jakobsson, Ulrika& Mäkilä, Ermei& Airaksinen, Anu J.& Alanen, Osku& Etilé, Asenath& Köster, Ulli…[et al.]. Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130235
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130235
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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