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Preparation and Characterization of PEG4000 PalmitatePEG8000 Palmitate-Solid Dispersion Containing the Poorly Water-Soluble Drug Andrographolide
المؤلفون المشاركون
Zeng, Qingyun
Ou, Liquan
Zhao, Guowei
Cai, Ping
Liao, Zhenggen
Dong, Wei
Liang, Xinli
المصدر
Advances in Polymer Technology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Solid dispersion (SD) is the effective approach to improve the dissolution rate and bioavailability of class II drugs with low water solubility and high tissue permeability in the Biopharmaceutics Classification System.
This study investigated the effects of polyethylene glycol (PEG) molecular weight in carrier material PEG palmitate on the properties of andrographolide (AG)-SD.
We prepared SDs containing the poorly water-soluble drug AG by the freeze-drying method.
The SDs were manufactured from two different polymers, PEG4000 palmitate and PEG8000 palmitate.
The physicochemical properties of the AG-SDs were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, dissolution testing, and so on.
We found that AG-PEG4000 palmitate-SD and AG-PEG8000 palmitate-SD were similar in the surface morphology, specific surface area, and pore volume.
Compared with the AG-PEG4000 palmitate-SD, the intermolecular interaction between PEG8000 palmitate and AG was stronger, and the thermal stability of AG-PEG8000 palmitate-SD was better.
In the meanwhile, the AG relative crystallinity was lower and the AG dissolution rate was faster in AG-PEG8000 palmitate-SD.
The results demonstrate that the increasing PEG molecular weight in the PEG palmitate can improve the compatibility between the poorly water-soluble drug and carrier material, which is beneficial to improve the SD thermal stability and increases the dissolution rate of poorly water-soluble drug in the SD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Qingyun& Ou, Liquan& Zhao, Guowei& Cai, Ping& Liao, Zhenggen& Dong, Wei…[et al.]. 2020. Preparation and Characterization of PEG4000 PalmitatePEG8000 Palmitate-Solid Dispersion Containing the Poorly Water-Soluble Drug Andrographolide. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1130243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Qingyun…[et al.]. Preparation and Characterization of PEG4000 PalmitatePEG8000 Palmitate-Solid Dispersion Containing the Poorly Water-Soluble Drug Andrographolide. Advances in Polymer Technology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1130243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Qingyun& Ou, Liquan& Zhao, Guowei& Cai, Ping& Liao, Zhenggen& Dong, Wei…[et al.]. Preparation and Characterization of PEG4000 PalmitatePEG8000 Palmitate-Solid Dispersion Containing the Poorly Water-Soluble Drug Andrographolide. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1130243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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