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Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies
المؤلفون المشاركون
Tai, Po-An
Li, Yu-Chuan (Jack)
Wu, Chieh-Chen
Wang, Yao-Chin
Poly, Tahmina Nasrin
Islam, Md Mohaimenul
Yang, Hsuan-Chia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Antidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression.
A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far.
Here, our aim is to assess the association between antidepressant use and risk of dementia in elderly patients.
We searched articles through MEDLINE, EMBASE, Google, and Google Scholar from inception to December 1, 2017, that reported on the association between antidepressant use and dementia risk.
Data were collected from each study independently, and study duplication was checked by at least three senior researchers based on a standardized protocol.
Summary relative risk (RR) with 95% CI was calculated by using a random-effects model.
We selected 9 out of 754 unique abstracts for full-text review using our predetermined selection criteria, and 5 out of these 9 studies, comprising 53,955 participants, met all of our inclusion criteria.
The overall pooled RR of dementia was 1.75 (95% CI: 1.033–2.964) for SSRIs whereas the overall pooled RR of dementia was 2.131 (95% CI: 1.427–3.184) for tricyclic use.
Also, MAOIs showed a high rate of increase with significant heterogeneity.
Our findings indicate that antidepressant use is significantly associated with an increased risk of developing dementia.
Therefore, we suggest physicians to carefully prescribe antidepressants, especially in elder patients.
Additionally, treatment should be stopped if any symptoms related to dementia are to be noticed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yao-Chin& Tai, Po-An& Poly, Tahmina Nasrin& Islam, Md Mohaimenul& Yang, Hsuan-Chia& Wu, Chieh-Chen…[et al.]. 2018. Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yao-Chin…[et al.]. Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies. Behavioural Neurology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yao-Chin& Tai, Po-An& Poly, Tahmina Nasrin& Islam, Md Mohaimenul& Yang, Hsuan-Chia& Wu, Chieh-Chen…[et al.]. Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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