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Toward the Optimization of (+)-[11C]PHNO Synthesis: Time Reduction and Process Validation
المؤلفون المشاركون
Wadsak, W.
Hacker, Marcus
Pfaff, Sarah
Philippe, Cécile
Nics, Lukas
Berroterán-Infante, Neydher
Pallitsch, Katharina
Rami-Mark, Christina
Weidenauer, Ana
Sauerzopf, Ulrich
Willeit, Matthäus
Mitterhauser, Markus
Pichler, Verena
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
(+)-[11C]PHNO, a dopamine D2/3 receptor agonistic radiotracer, is applied for investigating the dopaminergic system via positron emission tomography (PET).
An improved understanding of neuropsychiatric disorders associated with dysfunctions in the dopamine system and the underlying mechanism is a necessity in order to promote the development of new potential therapeutic drugs.
In contrast to other broadly applied 11C-radiopharmaceuticals, the production of this radiotracer requires a challenging four-step radiosynthesis involving harsh reaction conditions and reactants as well as an inert atmosphere.
Consequently, the production is prone to errors and troubleshooting after failed radiosyntheses remains time consuming.
Hence, we aimed to optimize the radiosynthesis of (+)-[11C]PHNO for achieving better activity yields without loss of product quality.
Therefore, we synthesized (+)-[11C]PHNO and omitted all heating and cooling steps leading to higher activity yields.
As a result, radiosynthesis fully conducted at room temperature led to a time-reduced production procedure that saves about 5 min, which is an appreciable decay-prevention of around 15% of the activity yield.
Additionally, we established a troubleshooting protocol by investigating reaction intermediates, byproducts, and impurities.
Indeed, partial runs enabled the assignment of byproducts to their associated error source.
Finally, we were able to generate a decision tree facilitating error detection in (+)-[11C]PHNO radiosynthesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pfaff, Sarah& Philippe, Cécile& Nics, Lukas& Berroterán-Infante, Neydher& Pallitsch, Katharina& Rami-Mark, Christina…[et al.]. 2019. Toward the Optimization of (+)-[11C]PHNO Synthesis: Time Reduction and Process Validation. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1130250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pfaff, Sarah…[et al.]. Toward the Optimization of (+)-[11C]PHNO Synthesis: Time Reduction and Process Validation. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1130250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pfaff, Sarah& Philippe, Cécile& Nics, Lukas& Berroterán-Infante, Neydher& Pallitsch, Katharina& Rami-Mark, Christina…[et al.]. Toward the Optimization of (+)-[11C]PHNO Synthesis: Time Reduction and Process Validation. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1130250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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