Prognostic Value of 18F-Fluorocholine PET Parameters in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Docetaxel
المؤلفون المشاركون
D'Ambrosio, Daniela
Gallivanone, F.
Quaquarini, E.
Sottotetti, F.
Hodolic, M.
Baiardi, P.
Palumbo, R.
Vellani, C.
Canevari, C.
Bernardo, A.
Porta, C.
Trifirò, G.
Castiglioni, Isabella
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aim.
The availability of new treatments for metastatic castrate-resistant prostate cancer (mCRPC) patients increases the need for reliable biomarkers to help clinicians to choose the better sequence strategy.
The aim of the present retrospective and observational work is to investigate the prognostic value of 18F-fluorocholine (18F-FCH) positron emission tomography (PET) parameters in mCRPC.
Materials and Methods.
Between March 2013 and August 2016, 29 patients with mCRPC were included.
They all received three-weekly docetaxel after androgen deprivation therapy, and they underwent 18F-FCH PET/computed tomography (CT) before and after the therapy.
Semi-quantitative indices such as maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean) with partial volume effect (PVC-SUV) correction, metabolically active tumour volume (MATV), and total lesion activity (TLA) with partial volume effect (PVC-TLA) correction were measured both in pre-treatment and post-treatment 18F-FCH PET/CT scans for each lesion.
Whole-body indices were calculated as sum of values measured for each lesion (SSUVmax, SPVC-SUV, SMATV, and STLA).
Progression-free survival (PFS) and overall survival (OS) were considered as clinical endpoints.
Univariate and multivariate hazard ratios for whole-body 18F-FCH PET indices were performed, and p<0.05 was considered as significant.
Results.
Cox regression analysis showed a statistically significant correlation between PFS, SMATV, and STLA.
No correlations between OS and 18F-FCH PET parameters were defined probably due to the small sample size.
Conclusions.
Semi-quantitative indices such as SMATV and STLA at baseline have a prognostic role in patients treated with docetaxel for mCRPC, suggesting a potential role of 18F-FCH PET/CT imaging in clinical decision-making.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quaquarini, E.& D'Ambrosio, Daniela& Sottotetti, F.& Gallivanone, F.& Hodolic, M.& Baiardi, P.…[et al.]. 2019. Prognostic Value of 18F-Fluorocholine PET Parameters in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Docetaxel. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1130253
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quaquarini, E.…[et al.]. Prognostic Value of 18F-Fluorocholine PET Parameters in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Docetaxel. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1130253
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quaquarini, E.& D'Ambrosio, Daniela& Sottotetti, F.& Gallivanone, F.& Hodolic, M.& Baiardi, P.…[et al.]. Prognostic Value of 18F-Fluorocholine PET Parameters in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Docetaxel. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1130253
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130253
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر