Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier
المؤلفون المشاركون
Conti, Allegra
Magnin, Rémi
Gerstenmayer, Matthieu
Tsapis, Nicolas
Dumont, Erik
Tillement, Olivier
Lux, François
Le Bihan, Denis
Mériaux, Sébastien
Della Penna, Stefania
Larrat, Benoit
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain.
We present here a study on the diffusion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization.
Three compounds were tested (MultiHance, Gadovist, and Dotarem).
We characterized their diffusion through in vivo experimental tests supported by theoretical models.
Specifically, by estimation of the free diffusion coefficients from in vitro studies and of apparent diffusion coefficients from in vivo experiments, we have assessed tortuosity in the right striatum of 9 Sprague Dawley rats through a model correctly describing both vascular permeability as a function of time and diffusion processes occurring in the brain tissue.
This model takes into account acoustic pressure, particle size, blood pharmacokinetics, and diffusion rates.
Our model is able to fully predict the result of a FUS-induced BBB opening experiment at long space and time scales.
Recovered values of tortuosity are in agreement with the literature and demonstrate that our improved model allows us to assess that the chosen permeabilization protocol preserves the integrity of the brain tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Conti, Allegra& Magnin, Rémi& Gerstenmayer, Matthieu& Tsapis, Nicolas& Dumont, Erik& Tillement, Olivier…[et al.]. 2019. Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1130325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Conti, Allegra…[et al.]. Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1130325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Conti, Allegra& Magnin, Rémi& Gerstenmayer, Matthieu& Tsapis, Nicolas& Dumont, Erik& Tillement, Olivier…[et al.]. Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1130325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر