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Dynamic Evaluation of Notch Signaling-Mediated Angiogenesis in Ischemic Rats Using Magnetic Resonance Imaging
المؤلفون المشاركون
Tian, Jia-qi
Zheng, Jia-jun
Hao, Xiao-zhu
Yin, Le-kang
Zhang, Xiao-xue
Li, Chan-chan
Feng, Xiao-yuan
Jiang, Min
Sun, Hua-ping
Zheng, Kang
Yang, Yan-mei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The Notch signaling pathway is involved in angiogenesis induced by brain ischemia and can be efficiently inhibited by the γ-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT).
The aim of the present study was to noninvasively investigate the effect of DAPT treatment on angiogenesis in brain repair after stroke using magnetic resonance imaging (MRI).
Methods.
Sprague-Dawley rats (n=40) were subjected to 90 minutes of transient middle cerebral artery (MCA) occlusion and treated with PBS (n=20) or DAPT (n=20) at 72 hours after the onset of ischemia.
MRI measurements including T2-weighted imaging (T2WI), susceptibility-weighted imaging (SWI), and cerebral blood flow (CBF) were performed at 24 hours after reperfusion and weekly up to 4 weeks using a 3-Tesla system.
Histological measurements were obtained at each time point after MRI scans.
Results.
SWI showed that DAPT treatment significantly enhanced angiogenesis in the ischemic boundary zone (IBZ) with respect to the control group, with local CBF in the angiogenic area elevated, along with increases in vascular density confirmed by histology.
Conclusion.
Treatment of ischemic stroke with DAPT significantly augments angiogenesis, which promotes poststroke brain remodeling by elevating CBF level, and these processes can be dynamically monitored and evaluated by MRI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Jia-qi& Zheng, Jia-jun& Hao, Xiao-zhu& Yin, Le-kang& Zhang, Xiao-xue& Li, Chan-chan…[et al.]. 2018. Dynamic Evaluation of Notch Signaling-Mediated Angiogenesis in Ischemic Rats Using Magnetic Resonance Imaging. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130334
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Jia-qi…[et al.]. Dynamic Evaluation of Notch Signaling-Mediated Angiogenesis in Ischemic Rats Using Magnetic Resonance Imaging. Behavioural Neurology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130334
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Jia-qi& Zheng, Jia-jun& Hao, Xiao-zhu& Yin, Le-kang& Zhang, Xiao-xue& Li, Chan-chan…[et al.]. Dynamic Evaluation of Notch Signaling-Mediated Angiogenesis in Ischemic Rats Using Magnetic Resonance Imaging. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130334
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130334
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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