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Biodistribution of [11C]-Metformin and mRNA Expression of Placentae Metformin Transporters in the Pregnant Chinchilla
المؤلفون المشاركون
Alstrup, Aage K. O.
Jakobsen, Steen
Pedersen, S. B.
Pedersen, Michael
Overgaard, Maria Dahl
Duvald, Christina Søndergaard
Vendelbo, Mikkel Holm
Mikkelsen, Emmeli
Ovesen, Per Glud
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
While metformin is the first-line pharmacological treatment of diabetes mellitus type 2, this drug is not considered safe to use in pregnant women because of its unknown consequences for the fetus.
In this study, we aimed to investigate the biodistribution of metformin in the pregnant chinchilla, a species exhibiting placental characteristics comparable with the pregnant woman.
Furthermore, we aimed to investigate the expression of metformin transporters in humans and chinchillas, respectively, in order to evaluate the pregnant chinchilla as a novel animal model for the use of metformin in pregnancy.
Methods.
Three chinchillas in the last part of gestation were injected with [11C]-metformin and scanned by PET/CT for 70 minutes to visualize the distribution.
To investigate the difference in expression of placenta transporters between humans and chinchillas, PCR was performed on samples from five chinchilla placentae and seven human placentae.
Results.
Dynamic PET with [11C]-metformin showed that the metformin distribution in chinchillas was similar to that in nonpregnant humans, with signal from kidneys, liver, bladder, and submandibular glands.
Conversely, no radioactive signal was observed from the fetuses, and no metformin was accumulated in the chinchilla fetus when measuring the SUV.
PCR of placental mRNA showed that the human placentae expressed OCT3, whereas the chinchilla placentae expressed OCT1.
Conclusion.
Since metformin did not pass the placenta barrier in the pregnant chinchilla, as it is known to do in humans, we do not suggest the chinchilla as a future animal model of metformin in pregnancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Overgaard, Maria Dahl& Duvald, Christina Søndergaard& Vendelbo, Mikkel Holm& Pedersen, S. B.& Jakobsen, Steen& Alstrup, Aage K. O.…[et al.]. 2019. Biodistribution of [11C]-Metformin and mRNA Expression of Placentae Metformin Transporters in the Pregnant Chinchilla. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1130403
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Overgaard, Maria Dahl…[et al.]. Biodistribution of [11C]-Metformin and mRNA Expression of Placentae Metformin Transporters in the Pregnant Chinchilla. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1130403
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Overgaard, Maria Dahl& Duvald, Christina Søndergaard& Vendelbo, Mikkel Holm& Pedersen, S. B.& Jakobsen, Steen& Alstrup, Aage K. O.…[et al.]. Biodistribution of [11C]-Metformin and mRNA Expression of Placentae Metformin Transporters in the Pregnant Chinchilla. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1130403
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130403
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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