Buprenorphine versus Morphine in Paediatric Acute Pain: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Murray, Nathan
Malla, Utsav
Vlok, Ruan
Scott, Alice
Chua, Olivia
Melhuish, Thomas
White, Leigh
المصدر
Critical Care Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-07
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
In lab-based studies, buprenorphine appears to have a ceiling effect on respiratory depression but not on analgesia.
There is increasing evidence in adult patients that buprenorphine has no ceiling effect on analgesia or side effects.
The aim of this study was to investigate the efficacy and adverse effects of buprenorphine versus morphine in paediatric acute pain.
Methods.
A systematic review of five databases was performed until May 2018.
Only randomised controlled trials were eligible for inclusion.
The outcomes of interest included pain, respiratory depression, nausea, sedation, dizziness, and pruritus.
Results.
Four randomised controlled trials (n=195) were included.
The only outcome measuring analgesic efficacy was time to breakthrough analgesia.
Buprenorphine had a significant increase in time to breakthrough analgesia by 114.98 minutes compared to morphine (95% CI = 42.94 to 187.01; I2 = 0; p=0.002).
There was no significant difference in the rates of adverse effects.
Conclusions.
Buprenorphine provided a longer duration of analgesia than morphine.
This in combination with its unique sublingual preparation could prove particularly advantageous in the paediatric population.
The studies included are likely underpowered to detect differences in the incidence of adverse effects; therefore, the same precautions should be taken as with any other opioid.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Murray, Nathan& Malla, Utsav& Vlok, Ruan& Scott, Alice& Chua, Olivia& Melhuish, Thomas…[et al.]. 2018. Buprenorphine versus Morphine in Paediatric Acute Pain: A Systematic Review and Meta-Analysis. Critical Care Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Murray, Nathan…[et al.]. Buprenorphine versus Morphine in Paediatric Acute Pain: A Systematic Review and Meta-Analysis. Critical Care Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1130429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Murray, Nathan& Malla, Utsav& Vlok, Ruan& Scott, Alice& Chua, Olivia& Melhuish, Thomas…[et al.]. Buprenorphine versus Morphine in Paediatric Acute Pain: A Systematic Review and Meta-Analysis. Critical Care Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر