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Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia
المؤلفون المشاركون
McAdams, Ryan M.
Pak, Daniel
Lalovic, Bojan
Phillips, Brian
Shen, Danny D.
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-25
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Dexmedetomidine is a promising sedative and analgesic for newborns with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).
Pharmacokinetics and safety of dexmedetomidine were evaluated in a phase I, single-center, open-label study to inform future trial strategies.
We recruited 7 neonates ≥36 weeks’ gestational age diagnosed with moderate-to-severe HIE, who received a continuous dexmedetomidine infusion during TH and the 6 h rewarming period.
Time course of plasma dexmedetomidine concentration was characterized by serial blood sampling during and after the 64.8 ± 6.9 hours of infusion.
Noncompartmental analysis yielded descriptive pharmacokinetic estimates: plasma clearance of 0.760 ± 0.155 L/h/kg, steady-state distribution volume of 5.22 ± 2.62 L/kg, and mean residence time of 6.84 ± 3.20 h.
Naive pooled and population analyses according to a one-compartment model provided similar estimates of clearance and distribution volume.
Overall, clearance was either comparable or lower, distribution volume was larger, and mean residence time or elimination half-life was longer in cooled newborns with HIE compared to corresponding estimates previously reported for uncooled (normothermic) newborns without HIE at comparable gestational and postmenstrual ages.
As a result, plasma concentrations in cooled newborns with HIE rose more slowly in the initial hours of infusion compared to predicted concentration-time profiles based on reported pharmacokinetic parameters in normothermic newborns without HIE, while similar steady-state levels were achieved.
No acute adverse events were associated with dexmedetomidine treatment.
While dexmedetomidine appeared safe for neonates with HIE during TH at infusion doses up to 0.4 μg/kg/h, a loading dose strategy may be needed to overcome the initial lag in rise of plasma dexmedetomidine concentration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McAdams, Ryan M.& Pak, Daniel& Lalovic, Bojan& Phillips, Brian& Shen, Danny D.. 2020. Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Anesthesiology Research and Practice،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1130528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McAdams, Ryan M.…[et al.]. Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Anesthesiology Research and Practice No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1130528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McAdams, Ryan M.& Pak, Daniel& Lalovic, Bojan& Phillips, Brian& Shen, Danny D.. Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Anesthesiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1130528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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