Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery
المؤلفون المشاركون
Mahjoubifard, Maziar
Heidari, Mehdi
Dahmardeh, Maryam
Mirtajani, Seyed Bashir
Jahangirifard, Alireza
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction and Objective.
Laryngoscopy and intubation are accompanied by sympathetic responses.
These transient responses appear as an increase in blood pressure and heart rate.
In patients with cardiovascular problems, the hemodynamic changes may lead to life-threatening risks, such as heart ischemia, acute heart failure, and cerebrovascular events.
Materials and Methods.
This clinical trial was conducted on 90 patients, aged 30–70 years, who had heart surgery.
The participants were categorized into three groups.
Group D received 1 µg/kg intravenous dexmedetomidine in 10 minutes, group L received 1.5 mg/kg lidocaine (1%) 90 seconds before intubation, and group F received 2 µg/kg fentanyl.
The vital signs (HR, SBP, DBP, and MAP) were measured before intubation and 1st, 3rd, 5th, and 10th minutes after intubation.
Data were analyzed with SPSS 19 software (chi-square, one-way ANOVA, or Kruskal–Wallis).
Results.
The age (P=0.389) and gender distributions of patients were similar in all three groups.
Dexmedetomidine significantly attenuated HR in the 3rd (P=0.001), 5th (P=0.001), and 10th (P=0.003) minutes after intervention.
It also reduced the systolic blood pressure in the 5th (P=0.024) and 10th (P=0.006) minutes.
This reduction was significantly higher in the dexmedetomidine group than that in the two other groups.
In addition, dexmedetomidine caused a greater reduction in MAP in the 1st (P=0.048), 5th (P=0.0001), and 10th (P=0.0001) minutes.
Discussion.
All three medications were effective in controlling HR; however, dexmedetomidine caused bradycardia in the 3rd, 5th, and 10th minutes.
Lidocaine resulted in an increase in MAP in the 1st minute after intubation; whereas, dexmedetomidine reduced MAP at the 5th and 10th minutes after intubation.
Changes in blood pressure and mean arterial pressure in the fentanyl group was lower than the two other groups.
Conclusion.
As a result, dexmedetomidine was not suitable for hemodynamic control and led to hypotension and bradycardia; on the other hand, fentanyl was more effective than two other medications in patients undergoing cardiac surgery.
This trial is registered with IRCT2017013132320N1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahjoubifard, Maziar& Heidari, Mehdi& Dahmardeh, Maryam& Mirtajani, Seyed Bashir& Jahangirifard, Alireza. 2020. Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery. Anesthesiology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1130538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahjoubifard, Maziar…[et al.]. Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery. Anesthesiology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1130538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahjoubifard, Maziar& Heidari, Mehdi& Dahmardeh, Maryam& Mirtajani, Seyed Bashir& Jahangirifard, Alireza. Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery. Anesthesiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1130538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر